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Profile of sleep disturbances in patients with recurrent depressive disorder or bipolar affective disorder in a tertiary sleep disorders service.
Drakatos, Panagis; O'Regan, David; Liao, Yingqi; Panayiotou, Constantinos; Higgins, Sean; Kabiljo, Renata; Benson, Joshua; Pool, Norman; Tahmasian, Masoud; Romigi, Andrea; Nesbitt, Alexander; Stokes, Paul R A; Kumari, Veena; Young, Allan H; Rosenzweig, Ivana.
Afiliación
  • Drakatos P; Sleep Disorders Centre, Guy's and St Thomas' NHS Foundation Trust, London, UK.
  • O'Regan D; Faculty of Life Sciences and Medicine, King's College London, London, UK.
  • Liao Y; Department of Neuroimaging, Sleep and Brain Plasticity Centre, Institute of Psychiatry, Psychology and Neuroscience (IoPPN), King's College London, De Crespigny Park, Box 089, London, SE5 8AF, UK.
  • Panayiotou C; Sleep Disorders Centre, Guy's and St Thomas' NHS Foundation Trust, London, UK.
  • Higgins S; Faculty of Life Sciences and Medicine, King's College London, London, UK.
  • Kabiljo R; Department of Neuroimaging, Sleep and Brain Plasticity Centre, Institute of Psychiatry, Psychology and Neuroscience (IoPPN), King's College London, De Crespigny Park, Box 089, London, SE5 8AF, UK.
  • Benson J; Department of Neuroimaging, Sleep and Brain Plasticity Centre, Institute of Psychiatry, Psychology and Neuroscience (IoPPN), King's College London, De Crespigny Park, Box 089, London, SE5 8AF, UK.
  • Pool N; Department of Neuroimaging, Sleep and Brain Plasticity Centre, Institute of Psychiatry, Psychology and Neuroscience (IoPPN), King's College London, De Crespigny Park, Box 089, London, SE5 8AF, UK.
  • Tahmasian M; Sleep Disorders Centre, Guy's and St Thomas' NHS Foundation Trust, London, UK.
  • Romigi A; Department of Neuroimaging, Sleep and Brain Plasticity Centre, Institute of Psychiatry, Psychology and Neuroscience (IoPPN), King's College London, De Crespigny Park, Box 089, London, SE5 8AF, UK.
  • Nesbitt A; Department of Neuroimaging, Sleep and Brain Plasticity Centre, Institute of Psychiatry, Psychology and Neuroscience (IoPPN), King's College London, De Crespigny Park, Box 089, London, SE5 8AF, UK.
  • Stokes PRA; Department of Biostatistics and Health Informatics, Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology and Neuroscience, King's College London, Denmark Hill, London, SE5 8AF, UK.
  • Kumari V; Sleep Disorders Centre, Guy's and St Thomas' NHS Foundation Trust, London, UK.
  • Young AH; Department of Neuropsychiatry, St George's Hospital, South West London and St George's Mental Health NHS Trust, London, UK.
  • Rosenzweig I; Institute of Neuroscience and Medicine Research, Brain and Behaviour (INM-7), Jülich Research Center, Jülich, Germany & Institute for Systems Neuroscience, Medical Faculty, Heinrich-Heine University, Düsseldorf, Germany.
Sci Rep ; 13(1): 8785, 2023 05 31.
Article en En | MEDLINE | ID: mdl-37258713
Bidirectional relationship between sleep disturbances and affective disorders is increasingly recognised, but its underlying mechanisms are far from clear, and there is a scarcity of studies that report on sleep disturbances in recurrent depressive disorder (RDD) and bipolar affective disorder (BPAD). To address this, we conducted a retrospective study of polysomnographic and clinical records of patients presenting to a tertiary sleep disorders clinic with affective disorders. Sixty-three BPAD patients (32 female; mean age ± S.D.: 41.8 ± 12.4 years) and 126 age- and gender-matched RDD patients (62 female; 41.5 ± 12.8) were studied. Whilst no significant differences were observed in sleep macrostructure parameters between BPAD and RDD patients, major differences were observed in comorbid sleep and physical disorders, both of which were higher in BPAD patients. Two most prevalent sleep disorders, namely obstructive sleep apnoea (OSA) (BPAD 50.8.0% vs RDD 29.3%, P = 0.006) and insomnia (BPAD 34.9% vs RDD 15.0%, P = 0.005) were found to be strongly linked with BPAD. In summary, in our tertiary sleep clinic cohort, no overt differences in the sleep macrostructure between BPAD and RDD patients were demonstrated. However, OSA and insomnia, two most prevalent sleep disorders, were found significantly more prevalent in patients with BPAD, by comparison to RDD patients. Also, BPAD patients presented with significantly more severe OSA, and with higher overall physical co-morbidity. Thus, our findings suggest an unmet/hidden need for earlier diagnosis of those with BPAD.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Trastorno Bipolar / Trastorno Depresivo / Trastornos del Inicio y del Mantenimiento del Sueño Tipo de estudio: Diagnostic_studies / Observational_studies / Risk_factors_studies Límite: Female / Humans Idioma: En Revista: Sci Rep Año: 2023 Tipo del documento: Article Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
Imprimir
XML
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Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Trastorno Bipolar / Trastorno Depresivo / Trastornos del Inicio y del Mantenimiento del Sueño Tipo de estudio: Diagnostic_studies / Observational_studies / Risk_factors_studies Límite: Female / Humans Idioma: En Revista: Sci Rep Año: 2023 Tipo del documento: Article Pais de publicación: Reino Unido