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Lymphocyte Subsets and Pulmonary Nodules to Predict the Progression of Sarcoidosis.
Danila, Edvardas; Aleksoniene, Regina; Besusparis, Justinas; Gruslys, Vygantas; Jurgauskiene, Laimute; Laurinaviciene, Aida; Laurinavicius, Arvydas; Mainelis, Antanas; Zablockis, Rolandas; Zeleckiene, Ingrida; Zurauskas, Edvardas; Malickaite, Radvile.
Afiliación
  • Danila E; Clinic of Chest Diseases, Immunology and Allergology, Faculty of Medicine, Vilnius University, 03101 Vilnius, Lithuania.
  • Aleksoniene R; Center of Pulmonology and Allergology, Vilnius University Hospital Santaros Klinikos, 08661 Vilnius, Lithuania.
  • Besusparis J; Center of Pulmonology and Allergology, Vilnius University Hospital Santaros Klinikos, 08661 Vilnius, Lithuania.
  • Gruslys V; National Center of Pathology, Vilnius University Hospital Santaros Klinikos, 08406 Vilnius, Lithuania.
  • Jurgauskiene L; Faculty of Medicine, Vilnius University, 03101 Vilnius, Lithuania.
  • Laurinaviciene A; Clinic of Chest Diseases, Immunology and Allergology, Faculty of Medicine, Vilnius University, 03101 Vilnius, Lithuania.
  • Laurinavicius A; Center of Pulmonology and Allergology, Vilnius University Hospital Santaros Klinikos, 08661 Vilnius, Lithuania.
  • Mainelis A; Clinic of Cardiac and Vascular Diseases, Faculty of Medicine, Vilnius University, 03101 Vilnius, Lithuania.
  • Zablockis R; Center of Laboratory Medicine, Vilnius University Hospital Santaros Klinikos, 08661 Vilnius, Lithuania.
  • Zeleckiene I; National Center of Pathology, Vilnius University Hospital Santaros Klinikos, 08406 Vilnius, Lithuania.
  • Zurauskas E; Faculty of Medicine, Vilnius University, 03101 Vilnius, Lithuania.
  • Malickaite R; National Center of Pathology, Vilnius University Hospital Santaros Klinikos, 08406 Vilnius, Lithuania.
Biomedicines ; 11(5)2023 May 13.
Article en En | MEDLINE | ID: mdl-37239108
The search for biological markers, which allow a relatively accurate assessment of the individual course of pulmonary sarcoidosis at the time of diagnosis, remains one of the research priorities in this field of pulmonary medicine. The aim of our study was to investigate possible prognostic factors for pulmonary sarcoidosis with a special focus on cellular immune inflammation markers. A 2-year follow-up of the study population after the initial prospective and simultaneous analysis of lymphocyte activation markers expression in the blood, as well as bronchoalveolar lavage fluid (BALF) and lung biopsy tissue of patients with newly diagnosed pulmonary sarcoidosis, was performed. We found that some blood and BAL fluid immunological markers and lung computed tomography (CT) patterns have been associated with a different course of sarcoidosis. We revealed five markers that had a significant negative association with the course of sarcoidosis (worsening pulmonary function tests and/or the chest CT changes)-blood CD4+CD31+ and CD4+CD44+ T lymphocytes, BALF CD8+CD31+ and CD8+CD103+ T lymphocytes and a number of lung nodules on chest CT at the time of the diagnosis. Cut-off values, sensitivity, specificity and odds ratio for predictors of sarcoidosis progression were calculated. These markers may be reasonable predictors of sarcoidosis progression.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Prognostic_studies / Risk_factors_studies Idioma: En Revista: Biomedicines Año: 2023 Tipo del documento: Article País de afiliación: Lituania Pais de publicación: Suiza
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Prognostic_studies / Risk_factors_studies Idioma: En Revista: Biomedicines Año: 2023 Tipo del documento: Article País de afiliación: Lituania Pais de publicación: Suiza