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Physical Characteristics and Biocompatibility of 3D-Printed Polylactic-Co-Glycolic Acid Membranes Used for Guided Bone Regeneration.
Petposri, Sidabhat; Thuaksuban, Nuttawut; Buranadham, Supanee; Suwanrat, Trin; Punyodom, Winita; Supphaprasitt, Woraporn.
Afiliación
  • Petposri S; Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Prince of Songkla University, Hatyai 90112, Songkhla, Thailand.
  • Thuaksuban N; Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Prince of Songkla University, Hatyai 90112, Songkhla, Thailand.
  • Buranadham S; Department of Prosthetic Dentistry, Faculty of Dentistry, Prince of Songkla University, Hatyai 90112, Songkhla, Thailand.
  • Suwanrat T; Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Prince of Songkla University, Hatyai 90112, Songkhla, Thailand.
  • Punyodom W; Department of Chemistry, Faculty of Science, Chiang Mai University, Amphur Muang 50200, Chiang Mai, Thailand.
  • Supphaprasitt W; Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Prince of Songkla University, Hatyai 90112, Songkhla, Thailand.
J Funct Biomater ; 14(5)2023 May 14.
Article en En | MEDLINE | ID: mdl-37233385
Bioresorbable polymeric membranes for guided bone regeneration (GBR) were fabricated using the three-dimensional printing technique. Membranes made of polylactic-co-glycolic acid (PLGA), which consist of lactic acid (LA) and glycolic acid in ratios of 10:90 (group A) and 70:30 (group B), were compared. Their physical characteristics including architecture, surface wettability, mechanical properties, and degradability were compared in vitro, and their biocompatibilities were compared in vitro and in vivo. The results demonstrated that the membranes of group B had mechanical strength and could support the proliferation of fibroblasts and osteoblasts significantly better than those of group A (p < 0.05). The degradation rate in Group B was significantly lower than that in Group A, but they significantly produced less acidic environment (p < 0.05). In vivo, the membranes of group B were compared with the commercially available collagen membranes (group C). The amount of newly formed bone of rat's calvarial defects covered with the membranes of group C was stable after week 2, whereas that of group B increased over time. At week 8, the new bone volumes in group B were greater than those in group C (p > 0.05). In conclusion, the physical and biological properties of the PLGA membrane (LA:GA, 70:30) were suitable for GBR.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: J Funct Biomater Año: 2023 Tipo del documento: Article País de afiliación: Tailandia Pais de publicación: Suiza
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: J Funct Biomater Año: 2023 Tipo del documento: Article País de afiliación: Tailandia Pais de publicación: Suiza