Drug Phase Transformation and Water Redistribution during Continuous Tablet Manufacturing: A Case Study of Carbamazepine Dihydrate.

Munjal, Bhushan; DeBoyace, Kevin; Cao, Fengjuan; Krzyzaniak, Joseph F; Arora, Kapildev K; Suryanarayanan, Raj

Munjal, Bhushan; DeBoyace, Kevin; Cao, Fengjuan; Krzyzaniak, Joseph F; Arora, Kapildev K; Suryanarayanan, Raj.

Afiliación

Munjal B; Department of Pharmaceutics, College of Pharmacy, University of Minnesota, Minneapolis, Minnesota 55455, United States.
DeBoyace K; Pfizer Worldwide Research and Development, Drug Product Design, Groton, Connecticut 06340, United States.
Cao F; Pfizer Worldwide Research and Development, Drug Product Design, San Diego, California 92121, United States.
Krzyzaniak JF; Pfizer Worldwide Research and Development, Drug Product Design, Groton, Connecticut 06340, United States.
Arora KK; Pfizer Worldwide Research and Development, Drug Product Design, Groton, Connecticut 06340, United States.
Suryanarayanan R; Department of Pharmaceutics, College of Pharmacy, University of Minnesota, Minneapolis, Minnesota 55455, United States.

Mol Pharm ; 20(7): 3427-3437, 2023 07 03.

Article en En | MEDLINE | ID: mdl-37232571

Asunto(s)

Carbamazepina; Agua; Humanos; Carbamazepina/química; Agua/química; Deshidratación; Polvos; Comprimidos; Difracción de Rayos X

Palabras clave

PCMM; carbamazepine; continous mixing; continuous manufacturing; dehydration; dibasic calcium phosphate; drug phase transformation; hydrate; moisture redistribution

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Carbamazepina / Agua Límite: Humans Idioma: En Revista: Mol Pharm Asunto de la revista: BIOLOGIA MOLECULAR / FARMACIA / FARMACOLOGIA Año: 2023 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos

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