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Barrett's Esophagus in Eosinophilic Esophagitis in Swiss Eosinophilic Esophagitis Cohort Study (SEECS).
Scherer, Roger; Schreiner, Philipp; Rossel, Jean-Benoit; Greuter, Thomas; Burri, Emanuel; Saner, Catherine; Schlag, Christoph; Safroneeva, Ekaterina; Schoepfer, Alain; Straumann, Alex; Biedermann, Luc.
Afiliación
  • Scherer R; Department of Gastroenterology and Hepatology, University Hospital Zurich, Zurich, Switzerland.
  • Schreiner P; Department of Gastroenterology and Hepatology, University Hospital Zurich, Zurich, Switzerland.
  • Rossel JB; CTU Bern, University of Bern, Bern, Switzerland.
  • Greuter T; Department of Gastroenterology and Hepatology, University Hospital Zurich, Zurich, Switzerland.
  • Burri E; Department of Gastroenterology and Hepatology, Cantonal Hospital Liestal, Liestal, Switzerland.
  • Saner C; Division of Gastroenterology and Hepatology, Centre Hospitalier Universitaire Vaudois (CHUV) and University of Lausanne, Lausanne, Switzerland.
  • Schlag C; Department of Gastroenterology and Hepatology, University Hospital Zurich, Zurich, Switzerland.
  • Safroneeva E; Institute of Social and Preventive Medicine, University of Bern, Bern, Switzerland.
  • Schoepfer A; Division of Gastroenterology and Hepatology, Centre Hospitalier Universitaire Vaudois (CHUV) and University of Lausanne, Lausanne, Switzerland.
  • Straumann A; Department of Gastroenterology and Hepatology, University Hospital Zurich, Zurich, Switzerland.
  • Biedermann L; Department of Gastroenterology and Hepatology, University Hospital Zurich, Zurich, Switzerland.
Dig Dis ; 41(5): 695-707, 2023.
Article en En | MEDLINE | ID: mdl-37231862
INTRODUCTION: There is a complex interrelationship between gastroesophageal reflux disease (GERD) and eosinophilic esophagitis (EoE) potentially promoting the occurrence and modulating severity of each other reciprocally. Presence of Barrett's esophagus (BE) is a defining factor for the diagnosis of GERD. While several studies investigated the potential impact of concomitant GERD on the presentation and course of EoE, little was known with regards to BE in EoE patients. METHODS: We analyzed prospectively collected clinical, endoscopic, and histological data from patients enrolled in the Swiss Eosinophilic Esophagitis Cohort Study (SEECS) regarding differences between EoE patients with (EoE/BE+) versus without BE (EoE/BE-) and determined the prevalence of BE in EoE patients. RESULTS: Among a total of 509 EoE patients included in our analysis, 24 (4.7%) had concomitant BE with a high male preponderance (EoE/BE+ 83.3% vs. EoE/BE- 74.4%). While there were no differences in dysphagia, odynophagia was significantly (12.5 vs. 3.1%, p = 0.047) more common in EoE/BE+ versus EoE/BE-. General well-being at last follow-up was significantly lower in EoE/BE+. Endoscopically, we observed an increased incidence of fixed rings in the proximal esophagus in EoE/BE+ (70.8 vs. 46.3% in EoE/BE-, p = 0.019) and a higher fraction of patients with a severe fibrosis in the proximal histological specimen (8.7 vs. 1.6% in EoE/BE, p = 0.017). CONCLUSION: Our study reveals that BE is twice as frequent in EoE patients compared to general population. Despite many similarities between EoE patients with and without BE, the finding of a more pronounced remodeling in EoE patients with Barrett is noteworthy.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Esófago de Barrett / Trastornos de Deglución / Reflujo Gastroesofágico / Esofagitis Eosinofílica Tipo de estudio: Diagnostic_studies / Etiology_studies / Incidence_studies / Observational_studies / Risk_factors_studies Límite: Humans / Male País/Región como asunto: Europa Idioma: En Revista: Dig Dis Asunto de la revista: GASTROENTEROLOGIA Año: 2023 Tipo del documento: Article País de afiliación: Suiza Pais de publicación: Suiza
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Esófago de Barrett / Trastornos de Deglución / Reflujo Gastroesofágico / Esofagitis Eosinofílica Tipo de estudio: Diagnostic_studies / Etiology_studies / Incidence_studies / Observational_studies / Risk_factors_studies Límite: Humans / Male País/Región como asunto: Europa Idioma: En Revista: Dig Dis Asunto de la revista: GASTROENTEROLOGIA Año: 2023 Tipo del documento: Article País de afiliación: Suiza Pais de publicación: Suiza