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Doppler Ultrasound Flow Reversal in the Superior Sagittal Sinus to Detect Cerebral Venous Congestion in Vein of Galen Malformation.
Schwarz, S; Brevis Nuñez, F; Dürr, N R; Brassel, F; Schlunz-Hendann, M; Feldkamp, A; Rosenbaum, T; Felderhoff-Müser, U; Schulz, K; Dohna-Schwake, C; Bruns, N.
Afiliación
  • Schwarz S; From the Clinic for Pediatrics and Adolescent Medicine (S.S., F.B.N., A.F., T.R.) simone.schwarz@sana.de.
  • Brevis Nuñez F; From the Clinic for Pediatrics and Adolescent Medicine (S.S., F.B.N., A.F., T.R.).
  • Dürr NR; Clinic for Radiology and Neuroradiology (N.R.D., F.B., M.S.-H., K.S.).
  • Brassel F; Clinic for Radiology and Neuroradiology (N.R.D., F.B., M.S.-H., K.S.).
  • Schlunz-Hendann M; Center for Pediatric Interventional Radiology/Neuroradiology and Interventional Treatment of Vascular Malformations (F.B.), Sana Clinics Duisburg, Duisburg, Germany.
  • Feldkamp A; Clinic for Radiology and Neuroradiology (N.R.D., F.B., M.S.-H., K.S.).
  • Rosenbaum T; From the Clinic for Pediatrics and Adolescent Medicine (S.S., F.B.N., A.F., T.R.).
  • Felderhoff-Müser U; From the Clinic for Pediatrics and Adolescent Medicine (S.S., F.B.N., A.F., T.R.).
  • Schulz K; Clinic for Pediatrics I (U.F.-M., C.D.-S., N.B.).
  • Dohna-Schwake C; Centre for Translational Neuro- and Behavioural Sciences (U.F.-M., C.D.-S., N.B.), University Hospital Essen, University of Duisburg-Essen, Essen, Germany.
  • Bruns N; Clinic for Radiology and Neuroradiology (N.R.D., F.B., M.S.-H., K.S.).
AJNR Am J Neuroradiol ; 44(6): 707-715, 2023 06.
Article en En | MEDLINE | ID: mdl-37230540
BACKGROUND AND PURPOSE: Vein of Galen malformation is a rare congenital cerebrovascular malformation. In affected patients, increased cerebral venous pressure constitutes an important etiologic factor for the development of brain parenchymal damage. The aim of this study was to investigate the potential of serial cerebral venous Doppler measurements to detect and monitor increased cerebral venous pressure. MATERIALS AND METHODS: This was a retrospective monocentric analysis of ultrasound examinations within the first 9 months of life in patients with vein of Galen malformation admitted at <28 days of life. Categorization of perfusion waveforms in the superficial cerebral sinus and veins into 6 patterns was based on antero- and retrograde flow components. We performed an analysis of flow profiles across time and correlation with disease severity, clinical interventions, and congestion damage on cerebral MR imaging. RESULTS: The study included 44 Doppler ultrasound examinations of the superior sagittal sinus and 36 examinations of the cortical veins from 7 patients. Doppler flow profiles before interventional therapy correlated with disease severity determined by the Bicêtre Neonatal Evaluation Score (Spearman ρ = -0.97, P = < .001). At this time, 4 of 7 patients (57.1%) showed a retrograde flow component in the superior sagittal sinus, whereas after embolization, none of the 6 treated patients presented with a retrograde flow component. Only patients with a high retrograde flow component (equal or more than one-third retrograde flow, n = 2) showed severe venous congestion damage on cerebral MR imaging. CONCLUSIONS: Flow profiles in the superficial cerebral sinus and veins appear to be a useful tool to noninvasively detect and monitor cerebral venous congestion in vein of Galen malformation.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Venas Cerebrales / Malformaciones de la Vena de Galeno / Hiperemia Tipo de estudio: Observational_studies / Risk_factors_studies Límite: Humans / Newborn Idioma: En Revista: AJNR Am J Neuroradiol Año: 2023 Tipo del documento: Article Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Venas Cerebrales / Malformaciones de la Vena de Galeno / Hiperemia Tipo de estudio: Observational_studies / Risk_factors_studies Límite: Humans / Newborn Idioma: En Revista: AJNR Am J Neuroradiol Año: 2023 Tipo del documento: Article Pais de publicación: Estados Unidos