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Comparing the unified protocol for transdiagnostic treatment of emotional disorders to prolonged exposure for the treatment of PTSD: Design of a non-inferiority randomized controlled trial.
Lau, W; Chisholm, K; Gallagher, M W; Felmingham, K; Murray, K; Pearce, A; Doyle, N; Alexander, S; O'Brien, H; Putica, A; Khatri, J; Bockelmann, P; Hosseiny, F; Librado, A; Notarianni, M; O'Donnell, M L.
Afiliación
  • Lau W; Phoenix Australia - Centre for Posttraumatic Mental Health, Department of Psychiatry, The University of Melbourne, Victoria, Australia.
  • Chisholm K; Phoenix Australia - Centre for Posttraumatic Mental Health, Department of Psychiatry, The University of Melbourne, Victoria, Australia.
  • Gallagher MW; Department of Psychology, The University of Houston, TX, USA.
  • Felmingham K; Melbourne School of Psychological Sciences, The University of Melbourne, Victoria, Australia.
  • Murray K; Phoenix Australia - Centre for Posttraumatic Mental Health, Department of Psychiatry, The University of Melbourne, Victoria, Australia.
  • Pearce A; Phoenix Australia - Centre for Posttraumatic Mental Health, Department of Psychiatry, The University of Melbourne, Victoria, Australia.
  • Doyle N; Phoenix Australia - Centre for Posttraumatic Mental Health, Department of Psychiatry, The University of Melbourne, Victoria, Australia.
  • Alexander S; Phoenix Australia - Centre for Posttraumatic Mental Health, Department of Psychiatry, The University of Melbourne, Victoria, Australia.
  • O'Brien H; Phoenix Australia - Centre for Posttraumatic Mental Health, Department of Psychiatry, The University of Melbourne, Victoria, Australia.
  • Putica A; Phoenix Australia - Centre for Posttraumatic Mental Health, Department of Psychiatry, The University of Melbourne, Victoria, Australia.
  • Khatri J; Canberra Health Services, Australian Capital Territory Government, Canberra, Australia.
  • Bockelmann P; Phoenix Australia - Centre for Posttraumatic Mental Health, Department of Psychiatry, The University of Melbourne, Victoria, Australia.
  • Hosseiny F; Atlas Institute for Veterans and Families, Ottawa, Canada.
  • Librado A; University of Ottawa Institute of Mental Health Research at The Royal, Canada.
  • Notarianni M; Atlas Institute for Veterans and Families, Ottawa, Canada.
  • O'Donnell ML; Atlas Institute for Veterans and Families, Ottawa, Canada.
Contemp Clin Trials Commun ; 33: 101134, 2023 Jun.
Article en En | MEDLINE | ID: mdl-37228903
Background: Prolonged Exposure (PE), a trauma-focused therapy, is one of the most efficacious treatments available for PTSD. However, many people with PTSD do not lose their diagnosis following delivery of PE. The Unified Protocol (UP) for Transdiagnostic Treatment of Emotional Disorders is a non-trauma focused treatment that may offer an alternative treatment for PTSD. Methods: This paper describes the study protocol for IMPACT, an assessor-blinded randomized controlled trial that examines the non-inferiority of UP relative to PE for participants who meet DSM-5 criteria for current PTSD. One hundred and twenty adult participants with PTSD will be randomized to receive either 10 × 90-min sessions of UP or PE with a trained provider. The primary outcome is severity of PTSD symptoms assessed by the Clinician Administered PTSD Scale for DSM-5 (CAPS-5) at post-treatment. Discussion: While evidence-based treatments are available for PTSD, high levels of treatment dropout and non-response require new approaches to be tested. The UP is based on emotion regulation theory and is effective in treating anxiety and depressive disorders, however, there has been limited application to PTSD. This is the first rigorous study comparing UP to PE in a non-inferiority randomized controlled trial and may help improve clinical outcomes for those with PTSD. Trial registration: This trial was prospectively registered with the Australian New Zealand Clinical Trials Registry, Trial ID (ACTRN12619000543189).
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Clinical_trials / Guideline Idioma: En Revista: Contemp Clin Trials Commun Año: 2023 Tipo del documento: Article País de afiliación: Australia Pais de publicación: Países Bajos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Clinical_trials / Guideline Idioma: En Revista: Contemp Clin Trials Commun Año: 2023 Tipo del documento: Article País de afiliación: Australia Pais de publicación: Países Bajos