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A meta-analysis of genome-wide association studies of childhood wheezing phenotypes identifies ANXA1 as a susceptibility locus for persistent wheezing.
Granell, Raquel; Curtin, John A; Haider, Sadia; Kitaba, Negusse Tadesse; Mathie, Sara A; Gregory, Lisa G; Yates, Laura L; Tutino, Mauro; Hankinson, Jenny; Perretti, Mauro; Vonk, Judith M; Arshad, Hasan S; Cullinan, Paul; Fontanella, Sara; Roberts, Graham C; Koppelman, Gerard H; Simpson, Angela; Turner, Steve W; Murray, Clare S; Lloyd, Clare M; Holloway, John W; Custovic, Adnan.
Afiliación
  • Granell R; MRC Integrative Epidemiology Unit, Department of Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, United Kingdom.
  • Curtin JA; Division of Infection, Immunity and Respiratory Medicine, School of Biological Sciences, The University of Manchester, Manchester Academic Health Science Centre, and Manchester University NHS Foundation Trust, Manchester, United Kingdom.
  • Haider S; National Heart and Lung Institute, Imperial College London, London, United Kingdom.
  • Kitaba NT; Human Development and Health, Faculty of Medicine, University of Southampton, Southampton, United Kingdom.
  • Mathie SA; National Heart and Lung Institute, Imperial College London, London, United Kingdom.
  • Gregory LG; National Heart and Lung Institute, Imperial College London, London, United Kingdom.
  • Yates LL; National Heart and Lung Institute, Imperial College London, London, United Kingdom.
  • Tutino M; Division of Infection, Immunity and Respiratory Medicine, School of Biological Sciences, The University of Manchester, Manchester Academic Health Science Centre, and Manchester University NHS Foundation Trust, Manchester, United Kingdom.
  • Hankinson J; Division of Infection, Immunity and Respiratory Medicine, School of Biological Sciences, The University of Manchester, Manchester Academic Health Science Centre, and Manchester University NHS Foundation Trust, Manchester, United Kingdom.
  • Perretti M; William Harvey Research Institute, Barts and The London School of Medicine Queen Mary University of London, London, United Kingdom.
  • Vonk JM; Department of Epidemiology, University of Groningen, University Medical Center Groningen\, Groningen, Netherlands.
  • Arshad HS; University of Groningen, University Medical Center Groningen, Groningen Research Institute for Asthma and COPD (GRIAC), Groningen, Netherlands.
  • Cullinan P; NIHR Southampton Biomedical Research Centre, University Hospitals Southampton NHS Foundation Trust, Southampton, United Kingdom.
  • Fontanella S; David Hide Asthma and Allergy Research Centre, Isle of Wight, United Kingdom.
  • Roberts GC; Clinical and Experimental Sciences, Faculty of Medicine, University of Southampton, Southampton, United Kingdom.
  • Koppelman GH; National Heart and Lung Institute, Imperial College London, London, United Kingdom.
  • Simpson A; National Heart and Lung Institute, Imperial College London, London, United Kingdom.
  • Turner SW; Human Development and Health, Faculty of Medicine, University of Southampton, Southampton, United Kingdom.
  • Murray CS; NIHR Southampton Biomedical Research Centre, University Hospitals Southampton NHS Foundation Trust, Southampton, United Kingdom.
  • Lloyd CM; David Hide Asthma and Allergy Research Centre, Isle of Wight, United Kingdom.
  • Holloway JW; University of Groningen, University Medical Center Groningen, Groningen Research Institute for Asthma and COPD (GRIAC), Groningen, Netherlands.
  • Custovic A; Department of Pediatric Pulmonology and Pediatric Allergology, University of Groningen, University Medical Center Groningen, Beatrix Children's Hospital, Groningen, Netherlands.
Elife ; 122023 05 25.
Article en En | MEDLINE | ID: mdl-37227431
Three-quarters of children hospitalized for wheezing or asthma symptoms are preschool-aged. Some will continue to experience breathing difficulties through childhood and adulthood. Others will undergo a complete resolution of their symptoms by the time they reach elementary school. The varied trajectories of young children with wheezing suggest that it is not a single disease. There are likely different genetic or environmental causes. Despite these differences, wheezing treatments for young children are 'one size fits all.' Studying the genetic underpinnings of wheezing may lead to more customized treatment options. Granell et al. studied the genetic architecture of different patterns of wheezing from infancy to adolescence. To do so, they used machine learning technology to analyze the genomes of 9,568 individuals, who participated in five studies in the United Kingdom from birth to age 18. The experiments found a new genetic variation in the ANXA1 gene linked with persistent wheezing starting in early childhood. By comparing mice with and without this gene, Granell et al. showed that the protein encoded by ANXA1 controls inflammation in the lungs in response to allergens. Animals lacking the protein develop worse lung inflammation after exposure to dust mite allergens. Identifying a new gene linked to a specific subtype of wheezing might help scientists develop better strategies to diagnose, treat, and prevent asthma. More studies are needed on the role of the protein encoded by ANXA1 in reducing allergen-triggered lung inflammation to determine if this protein or therapies that boost its production may offer relief for chronic lung inflammation.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Asma / Hipersensibilidad Tipo de estudio: Diagnostic_studies / Prognostic_studies / Risk_factors_studies / Systematic_reviews Límite: Animals Idioma: En Revista: Elife Año: 2023 Tipo del documento: Article País de afiliación: Reino Unido Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Asma / Hipersensibilidad Tipo de estudio: Diagnostic_studies / Prognostic_studies / Risk_factors_studies / Systematic_reviews Límite: Animals Idioma: En Revista: Elife Año: 2023 Tipo del documento: Article País de afiliación: Reino Unido Pais de publicación: Reino Unido