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Trace analysis of benzophenone-type UV filters in water and their effects on human estrogen and androgen receptors.
Carstensen, Lale; Zippel, Rene; Fiskal, Ron; Börnick, Hilmar; Schmalz, Viktor; Schubert, Sara; Schaffer, Mario; Jungmann, Dirk; Stolte, Stefan.
Afiliación
  • Carstensen L; Institute of Water Chemistry, Technische Universität Dresden, 01069 Dresden, Germany.
  • Zippel R; Institute of Water Chemistry, Technische Universität Dresden, 01069 Dresden, Germany.
  • Fiskal R; Institute of Water Chemistry, Technische Universität Dresden, 01069 Dresden, Germany.
  • Börnick H; Institute of Water Chemistry, Technische Universität Dresden, 01069 Dresden, Germany.
  • Schmalz V; Institute of Water Chemistry, Technische Universität Dresden, 01069 Dresden, Germany.
  • Schubert S; Institute of Hydrobiology, Technische Universität, 01069 Dresden, Germany; Institute of Clinical Pharmacology, Faculty of Medicine Carl Gustav Carus, Technische Universität Dresden, 01307 Dresden, Germany.
  • Schaffer M; Lower Saxony Water Management, Coastal Defence, and Nature Conservation Agency, 31135 Hildesheim, Germany.
  • Jungmann D; Institute of Hydrobiology, Technische Universität, 01069 Dresden, Germany; University of the Free State, Centre for Environmental Management, Faculty of Natural and Agricultural Sciences, Bloemfontein 9300, Republic of South Africa.
  • Stolte S; Institute of Water Chemistry, Technische Universität Dresden, 01069 Dresden, Germany. Electronic address: stefan.stolte@tu-dresden.de.
J Hazard Mater ; 456: 131617, 2023 08 15.
Article en En | MEDLINE | ID: mdl-37224711
To carry out risk assessments of benzophenone-type UV filters (BPs), fast and accurate analytical methods are crucial to determine and monitor levels in the environment. This study presents an LC-MS/MS method that requires minimal sample preparation and yet can identify 10 different BPs in environmental samples such as surface or wastewater resulting in a LOQ range from 2 to 1060 ng/L. The method suitability was tested through environmental monitoring, which showed that, BP-4 is the most abundant derivative found in the surface waters of Germany, India, South Africa and Vietnam. BP-4 levels correlate with the WWTP effluent fraction of the respective river for selected samples in Germany. Peak values of 171 ng/L for 4-hydroxybenzophenone (4-OH-BP), as measured in Vietnamese surface water, already exceed the PNEC value of 80 ng/L, elevating 4-OH-BP to the status of a new pollutant that needs more frequent monitoring. Moreover, this study reveals that during biodegradation of benzophenone in river water, the transformation product 4-OH-BP is formed which contain structural alerts for estrogenic activity. By using yeast-based reporter gene assays, this study provides bio-equivalents of 9 BPs, 4-OH-BP, 2,3,4-tri-OH-BP, 4-cresol and benzoate and complements the existing structure-activities relationships of BPs and their degradation products.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Contaminantes Químicos del Agua / Receptores Androgénicos Límite: Humans Idioma: En Revista: J Hazard Mater Asunto de la revista: SAUDE AMBIENTAL Año: 2023 Tipo del documento: Article País de afiliación: Alemania Pais de publicación: Países Bajos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Contaminantes Químicos del Agua / Receptores Androgénicos Límite: Humans Idioma: En Revista: J Hazard Mater Asunto de la revista: SAUDE AMBIENTAL Año: 2023 Tipo del documento: Article País de afiliación: Alemania Pais de publicación: Países Bajos