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Female reproductive dormancy in Drosophila is regulated by DH31-producing neurons projecting into the corpus allatum.
Kurogi, Yoshitomo; Imura, Eisuke; Mizuno, Yosuke; Hoshino, Ryo; Nouzova, Marcela; Matsuyama, Shigeru; Mizoguchi, Akira; Kondo, Shu; Tanimoto, Hiromu; Noriega, Fernando G; Niwa, Ryusuke.
Afiliación
  • Kurogi Y; Degree Programs in Life and Earth Sciences, Graduate School of Science and Technology , University of Tsukuba, Tennodai 1-1-1, Tsukuba, Ibaraki 305-8572, Japan.
  • Imura E; Graduate School of Life and Environmental Sciences , University of Tsukuba, Tennodai 1-1-1, Tsukuba, Ibaraki 305-8572, Japan.
  • Mizuno Y; Life Science Center for Survival Dynamics , Tsukuba Advanced Research Alliance (TARA), University of Tsukuba, Tennodai 1-1-1, Tsukuba, Ibaraki 305-8577, Japan.
  • Hoshino R; Degree Programs in Life and Earth Sciences, Graduate School of Science and Technology , University of Tsukuba, Tennodai 1-1-1, Tsukuba, Ibaraki 305-8572, Japan.
  • Nouzova M; Degree Programs in Life and Earth Sciences, Graduate School of Science and Technology , University of Tsukuba, Tennodai 1-1-1, Tsukuba, Ibaraki 305-8572, Japan.
  • Matsuyama S; Department of Biological Sciences and BSI, Florida International University, 11200 SW 8th street, Miami, FL 33199, USA.
  • Mizoguchi A; Institute of Parasitology, Biology Center of the Academy of Sciences of the Czech Republic,37005, Ceské Budejovice, Czech Republic.
  • Kondo S; Faculty of Life and Environmental Sciences, University of Tsukuba, Tennodai 1-1-1, Tsukuba, Ibaraki 305-8572, Japan.
  • Tanimoto H; Division of Liberal Arts and Sciences, Aichi Gakuin University, 12 Araike, Iwasaki-cho, Nisshin, Aichi 470-0195, Japan.
  • Noriega FG; Department of Biological Science and Technology, Faculty of Advanced Engineering, Tokyo University of Science, Niijuku 6-3-1, Katsushika-ku, Tokyo 125-8585, Japan.
  • Niwa R; Invertebrate Genetics Laboratory, National Institute of Genetics, Yata 111, Mishima, Shizuoka 411-8540, Japan.
Development ; 150(10)2023 05 15.
Article en En | MEDLINE | ID: mdl-37218457
Female insects can enter reproductive diapause, a state of suspended egg development, to conserve energy under adverse environments. In many insects, including the fruit fly, Drosophila melanogaster, reproductive diapause, also frequently called reproductive dormancy, is induced under low-temperature and short-day conditions by the downregulation of juvenile hormone (JH) biosynthesis in the corpus allatum (CA). In this study, we demonstrate that neuropeptide Diuretic hormone 31 (DH31) produced by brain neurons that project into the CA plays an essential role in regulating reproductive dormancy by suppressing JH biosynthesis in adult D. melanogaster. The CA expresses the gene encoding the DH31 receptor, which is required for DH31-triggered elevation of intracellular cAMP in the CA. Knocking down Dh31 in these CA-projecting neurons or DH31 receptor in the CA suppresses the decrease of JH titer, normally observed under dormancy-inducing conditions, leading to abnormal yolk accumulation in the ovaries. Our findings provide the first molecular genetic evidence demonstrating that CA-projecting peptidergic neurons play an essential role in regulating reproductive dormancy by suppressing JH biosynthesis.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Drosophila melanogaster / Hormonas de Insectos Límite: Animals Idioma: En Revista: Development Asunto de la revista: BIOLOGIA / EMBRIOLOGIA Año: 2023 Tipo del documento: Article País de afiliación: Japón Pais de publicación: Reino Unido
Texto completo
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XML
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Drosophila melanogaster / Hormonas de Insectos Límite: Animals Idioma: En Revista: Development Asunto de la revista: BIOLOGIA / EMBRIOLOGIA Año: 2023 Tipo del documento: Article País de afiliación: Japón Pais de publicación: Reino Unido