Discovery of intracellular self-assembly protein degraders driven by tumor-specific activatable bioorthogonal reaction.

Si, Ru; Hai, Ping; Zheng, Yongbiao; Wang, Jin; Zhang, Qingqing; Li, Yanchen; Pan, Xiaoyan; Zhang, Jie

Si, Ru; Hai, Ping; Zheng, Yongbiao; Wang, Jin; Zhang, Qingqing; Li, Yanchen; Pan, Xiaoyan; Zhang, Jie.

Afiliación

Si R; School of Pharmacy, Health Science Center, Xi'an Jiaotong University, Xi'an, 710061, China.
Hai P; NMPA Key Laboratory for Quality Control of Traditional Chinese and Tibetan Medicine, Qinghai Provincial Drug Inspection and Testing Institute, Xining, 810016, China.
Zheng Y; NMPA Key Laboratory for Quality Control of Traditional Chinese and Tibetan Medicine, Qinghai Provincial Drug Inspection and Testing Institute, Xining, 810016, China.
Wang J; School of Pharmacy, Health Science Center, Xi'an Jiaotong University, Xi'an, 710061, China.
Zhang Q; School of Pharmacy, Health Science Center, Xi'an Jiaotong University, Xi'an, 710061, China.
Li Y; School of Pharmacy, Health Science Center, Xi'an Jiaotong University, Xi'an, 710061, China.
Pan X; School of Pharmacy, Health Science Center, Xi'an Jiaotong University, Xi'an, 710061, China.
Zhang J; School of Pharmacy, Health Science Center, Xi'an Jiaotong University, Xi'an, 710061, China. Electronic address: zhj8623@mail.xjtu.edu.cn.

Eur J Med Chem ; 257: 115497, 2023 Sep 05.

Article en En | MEDLINE | ID: mdl-37216813

Asunto(s)

Cobre; Neoplasias; Humanos; Alquinos; Apoptosis; Azidas; Quimera Dirigida a la Proteólisis

Palabras clave

Azide and alkyne; Click reaction; Endogenous copper-catalyzed; Self-assembled PROTAC; Tumor-targeting

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Cobre / Neoplasias Límite: Humans Idioma: En Revista: Eur J Med Chem Año: 2023 Tipo del documento: Article País de afiliación: China Pais de publicación: Francia

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