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Oncogenic roles and related mechanisms of the long non-coding RNA MINCR in human cancers.
Chao, Ce; Tang, Renzhe; Zhao, Jiamin; Di, Dongmei; Qian, Yongxiang; Wang, Bin.
Afiliación
  • Chao C; Department of Cardiothoracic Surgery, The Third Affiliated Hospital of Soochow University, Changzhou, China.
  • Tang R; Department of Cardiothoracic Surgery, The Third Affiliated Hospital of Soochow University, Changzhou, China.
  • Zhao J; Department of Respiratory Medicine, The Third Affiliated Hospital of Soochow University, Changzhou, China.
  • Di D; Department of Cardiothoracic Surgery, The Third Affiliated Hospital of Soochow University, Changzhou, China.
  • Qian Y; Department of Cardiothoracic Surgery, The Third Affiliated Hospital of Soochow University, Changzhou, China.
  • Wang B; Department of Cardiothoracic Surgery, The Third Affiliated Hospital of Soochow University, Changzhou, China.
Front Cell Dev Biol ; 11: 1087337, 2023.
Article en En | MEDLINE | ID: mdl-37215074
Long non-coding RNAs (lncRNAs) play vital roles in regulating epigenetic mechanisms and gene expression levels, and their dysregulation is closely associated with a variety of diseases such as cancer. Several studies have demonstrated that lncRNAs are dysregulated during tumor progression. Recently, the MYC-induced long non-coding RNA MINCR, a newly identified lncRNA, has been demonstrated to act as an oncogene in different cancers, including gallbladder cancer, hepatocellular cancer, colorectal cancer, non-small cell lung cancer, oral squamous cell carcinoma, nasopharyngeal cancer, and glioma. Moreover, MINCR has been reported to act as a biomarker in the prognosis of patients with different cancers. In this review, we summarize and analyze the oncogenic roles of MINCR in a variety of human cancers in terms of its clinical significance, biological functions, cellular activities, and regulatory mechanism. Our analysis of the literature suggests that MINCR has potential as a novel biomarker and therapeutic target in human cancers.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Front Cell Dev Biol Año: 2023 Tipo del documento: Article País de afiliación: China Pais de publicación: Suiza
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Front Cell Dev Biol Año: 2023 Tipo del documento: Article País de afiliación: China Pais de publicación: Suiza