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Triplet Strategies in Metastatic Clear Cell Renal Cell Carcinoma: A Worthy Option in the First-Line Setting?
Fahey, Catherine C; Shevach, Jeffrey W; Flippot, Ronan; Albiges, Laurence; Haas, Naomi B; Beckermann, Kathryn E.
Afiliación
  • Fahey CC; Division of Hematology Oncology, Vanderbilt University Medical Center, Nashville, TN.
  • Shevach JW; Vanderbilt-Ingram Cancer Center, Nashville, TN.
  • Flippot R; Abramson Cancer Center, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA.
  • Albiges L; Department of Cancer Medicine, Gustave Roussy, Paris Saclay University, Villejuif, France.
  • Haas NB; Department of Cancer Medicine, Gustave Roussy, Paris Saclay University, Villejuif, France.
  • Beckermann KE; Abramson Cancer Center, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA.
Am Soc Clin Oncol Educ Book ; 43: e389650, 2023 May.
Article en En | MEDLINE | ID: mdl-37207297
Significant strides have been made in the frontline treatment of patients with advanced clear cell renal cell carcinoma (ccRCC). There are multiple standard-of-care doublet regimens consisting of either the combined dual immune checkpoint inhibitors, ipilimumab and nivolumab, or combinations of a vascular endothelial growth factor receptor tyrosine kinase inhibitor and an immune checkpoint inhibitor. Currently, there is an emergence of clinical trials examining triplet combinations. In COSMIC-313, a randomized phase III trial for patients with untreated advanced ccRCC, the triplet combination of ipilimumab, nivolumab, and cabozantinib was compared with a contemporary control arm of ipilimumab and nivolumab. While patients receiving the triplet regimen demonstrated improved progression-free survival, these patients also experienced greater toxicity and the overall survival data are still maturing. In this article, we discuss the role of doublet therapy as standard of care, the current data available for the promise of triplet therapy, the rationale to continue pursuing trials with triplet combinations, and factors for clinicians and patients to consider when choosing among frontline treatments. We present ongoing trials with an adaptive design that may serve as alternative methods for escalating from doublet to triplet regimens in the frontline setting and explore clinical factors and emerging predictive biomarkers (both baseline and dynamic) that may guide future trial design and frontline treatment for patients with advanced ccRCC.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Carcinoma de Células Renales / Neoplasias Renales Tipo de estudio: Clinical_trials / Prognostic_studies Límite: Humans Idioma: En Revista: Am Soc Clin Oncol Educ Book Año: 2023 Tipo del documento: Article Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Carcinoma de Células Renales / Neoplasias Renales Tipo de estudio: Clinical_trials / Prognostic_studies Límite: Humans Idioma: En Revista: Am Soc Clin Oncol Educ Book Año: 2023 Tipo del documento: Article Pais de publicación: Estados Unidos