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Presence of tubuloreticular inclusions in ultrastructural studies of renal biopsies in children with lupus nephropathy - one-center preliminary study.
Koszutski, Tomasz; Mielanczyk, Lukasz; Kucharska, Grazyna; Matysiak, Natalia; Wiernik, Agnieszka; Kudela, Grzegorz; Hyla-Klekot, Lidia.
Afiliación
  • Koszutski T; Department of Pediatric Surgery and Urology, Medical University of Silesia, Katowice, Poland.
  • Mielanczyk L; Department of Histology and Cell Pathology, FMS in Zabrze, Medical University of Silesia, Katowice, Poland.
  • Kucharska G; Department of Pediatric Nephrology, Team of Municipal Hospitals in Chorzów, Poland.
  • Matysiak N; Department of Histology and Cell Pathology, FMS in Zabrze, Medical University of Silesia, Katowice, Poland.
  • Wiernik A; Department of Pediatric Surgery and Urology, Medical University of Silesia, Katowice, Poland.
  • Kudela G; Department of Pediatric Surgery and Urology, Medical University of Silesia, Katowice, Poland.
  • Hyla-Klekot L; Department of Pediatric Surgery and Urology, Medical University of Silesia, Katowice, Poland.
Cent Eur J Immunol ; 48(1): 26-34, 2023.
Article en En | MEDLINE | ID: mdl-37206592
Introduction: Juvenile systemic lupus erythematosus (jSLE) is an autoimmune disease that develops as a result of multi-level immune dysregulation, including the interferon pathway. Nephropathy develops at an early stage and eventually affects 90% of patients. A renal biopsy allows one to classify lupus nephritis and determine the proper treatment. Biopsy assessment should be done not only in a light microscope but also in a transmission electron microscope (TEM). Its usage may reveal the presence of intracellular tubuloreticular inclusions (TRIs), considered as a morphological marker of interferon hyperactivity. Material and methods: Renal biopsies of 10 children with jSLE and nephropathy were analyzed in TEM. The location, structure, and size of TRIs were assessed. Demographic data, nephropathy manifestation, non-renal symptoms, and serological activity of lupus were analyzed. Results: All the patients were female with an average onset at 12.7 years of age and met SLE criteria. Nephropathy manifested with proteinuria (n = 10) and hematuria (n = 6). Glomerular filtration rate (GFR) was normal in all patients. In three children with early disease onset, it manifested with hematological disorders. TRIs were revealed in 7 biopsies, with the highest expression in the youngest children, with peripheral cytopenia, membranous glomerulonephritis, and lupus nephritis. Conclusions: Demonstration of TRIs in renal biopsies of children with juvenile systemic lupus may confirm the diagnosis of lupus nephritis and is a sign of involvement of the interferon pathway at the early stage of the disease.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Cent Eur J Immunol Año: 2023 Tipo del documento: Article País de afiliación: Polonia Pais de publicación: Polonia
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Cent Eur J Immunol Año: 2023 Tipo del documento: Article País de afiliación: Polonia Pais de publicación: Polonia