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A 2-year longitudinal randomized controlled trial examining the transfer of speed of processing training to secondary cognitive domains in middle-aged and older adults with HIV-associated neurocognitive disorder: Results of the think fast study.
Vance, David E; Fazeli, Pariya L; Azuero, Andres; Frank, Jennifer S; Wadley, Virginia G; Raper, James L; Pope, Caitlin N; Ball, Karlene K.
Afiliación
  • Vance DE; School of Nursing, University of Alabama at Birmingham, Birmingham, AL, USA.
  • Fazeli PL; School of Nursing, University of Alabama at Birmingham, Birmingham, AL, USA.
  • Azuero A; School of Nursing, University of Alabama at Birmingham, Birmingham, AL, USA.
  • Frank JS; School of Nursing, University of Alabama at Birmingham, Birmingham, AL, USA.
  • Wadley VG; School of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA.
  • Raper JL; The 1917 (HIV/AIDS) Clinic, School of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA.
  • Pope CN; Department of Health, Behavior & Society, University of Kentucky, Lexington, KY, USA.
  • Ball KK; Department of Psychology, University of Alabama at Birmingham, Birmingham, AL, USA.
Clin Neuropsychol ; 38(2): 471-492, 2024 02.
Article en En | MEDLINE | ID: mdl-37191339
OBJECTIVE: As people with HIV (PWH) age, they are at-risk of developing cognitive impairments compared to their seronegative counterparts. Although speed of processing (SOP) training may help improve this cognitive ability, less work has examined transfer to other cognitive domains. This study examined the effect of SOP training has on secondary cognitive domains in PWH aged 40+ years. METHOD: In this 3-group 2-year longitudinal study, 216 PWH with HIV-associated neurocognitive disorder (HAND) or borderline HAND were randomized to either: (1) 10 h of SOP training (n = 70); (2) 20 h of SOP training (n = 73); or (3) 10 h of an active control training (n = 73). Participants completed a comprehensive cognitive battery at baseline, immediately after training, and at 1 and 2 years. This battery yielded global and domain specific T-scores as well as a cognitive impairment variable. Generalized linear mixed-effect models were fitted to estimate between-group mean differences at the follow-up time-points adjusted for baseline. RESULTS: No clinically or statistically significant improvements in any of the cognitive outcomes were observed. A sensitivity analysis was conducted; conclusions replicated those of the main analysis, with two exceptions: Global Function T and Psychomotor Speed T showed relevant training improvements among the intervention groups over the control group at the immediate post time point. CONCLUSIONS: Although SOP training has been shown to improve cognitive abilities that correspond to driving and mobility, such training has limited therapeutic utility in improving cognition in other domains in PWH with HAND.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Infecciones por VIH / Cognición Tipo de estudio: Clinical_trials / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Aged / Humans / Middle aged Idioma: En Revista: Clin Neuropsychol Asunto de la revista: NEUROLOGIA / PSICOLOGIA Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Infecciones por VIH / Cognición Tipo de estudio: Clinical_trials / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Aged / Humans / Middle aged Idioma: En Revista: Clin Neuropsychol Asunto de la revista: NEUROLOGIA / PSICOLOGIA Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Reino Unido