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The Role of Axillary SUVmax in 18F-FDG PET/CT in Predicting the Number of Axillary Metastases of Breast Cancer.
Karabacak, Ufuk; Turkan, Halil; Coskun, Gokhan; Mollaoglu, Murat Can; Hasbek, Zekiye; Karadayi, Kursat.
Afiliación
  • Karabacak U; Department of Surgical Oncology, Sivas Numune Hospital, Sivas, Turkiye.
  • Turkan H; Department of Surgical Oncology, Sanliurfa Mehmet Akif Inan Training and Research Hospital, Sanliurfa, Turkiye.
  • Coskun G; Department of Surgical Oncology, Tokat State Hospital, Tokat, Turkiye.
  • Mollaoglu MC; Department of Surgical Oncology, Sivas Numune Hospital, Sivas, Turkiye.
  • Hasbek Z; Department of Nuclear Medicine, Faculty of Medicine, Cumhuriyet University, Sivas, Turkiye.
  • Karadayi K; Department of Surgical Oncology, Faculty of Medicine, Cumhuriyet University, Sivas, Turkiye.
J Coll Physicians Surg Pak ; 33(4): 374-379, 2023 Apr.
Article en En | MEDLINE | ID: mdl-37190706
OBJECTIVE: To investigate the role of positron emission tomography/computed tomography (PET-CT) in determining the maximum number of axillary lymph node metastasis (ALNM) detectable in sentinel lymph node biopsy (SLNB). STUDY DESIGN: Observational study. Place and Duration of the Study: Sivas Cumhuriyet University Faculty of Medicine, Turkiye, from January 2015 to August 2021. METHODOLOGY: A total of 104 breast cancer patients who underwent surgery after a PET-CT scan were examined. A receiver operating characteristic (ROC) analysis was utilised to determine optimal cut-off values for the standardised uptake values of the primary tumour (pSUVmax) and axillary lymph nodes (nSUVmax) in the presence of ALNM and the presence of more than two ALNMs. RESULTS: The presence of more than two ALNMs was associated with pSUVmax, nSUVmax, LVI, and the number of LNs detected on PET-CT. In the ROC analysis, for the ability to predict more than two ALNMs in SLNB/axillary lymph node dissection (ALND), cut-offvalues were calculated as 4.65 for pSUVmax (AUC=0.669, sensitivity=66.7%, specificity=62%, PPV=0.482, NPV=0.800, p=0.006) and 1.75 for nSUVmax (AUC=0.838, sensitivity=81.8%, specificity=88.7%, PPV= 0.676, NPV=0.913, p<0.001). CONCLUSION: Low sensitivity, NPV, and accuracy values that limit the use of PET-CT in preoperative axillary evaluation can be increased by targeting the criterion of more than two ALNMs. Thus, PET-CT can be used more effectively in axilla management. KEY WORDS: Breast cancer, Positron emission tomography, SUVmax values, Axillary lymph node, ACOSOG Z0011.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias de la Mama / Tomografía Computarizada por Tomografía de Emisión de Positrones Tipo de estudio: Diagnostic_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Female / Humans Idioma: En Revista: J Coll Physicians Surg Pak Asunto de la revista: MEDICINA Año: 2023 Tipo del documento: Article Pais de publicación: Pakistán
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias de la Mama / Tomografía Computarizada por Tomografía de Emisión de Positrones Tipo de estudio: Diagnostic_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Female / Humans Idioma: En Revista: J Coll Physicians Surg Pak Asunto de la revista: MEDICINA Año: 2023 Tipo del documento: Article Pais de publicación: Pakistán