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Subcortical functional connectivity gradients in temporal lobe epilepsy.
Lucas, Alfredo; Mouchtaris, Sofia; Cornblath, Eli J; Sinha, Nishant; Caciagli, Lorenzo; Hadar, Peter; Gugger, James J; Das, Sandhitsu; Stein, Joel M; Davis, Kathryn A.
Afiliación
  • Lucas A; Perelman School of Medicine, University of Pennsylvania, United States; Department of Bioengineering, University of Pennsylvania, United States. Electronic address: alfredo.lucas@pennmedicine.upenn.edu.
  • Mouchtaris S; Department of Bioengineering, University of Pennsylvania, United States.
  • Cornblath EJ; Department of Neurology, University of Pennsylvania, United States.
  • Sinha N; Department of Neurology, University of Pennsylvania, United States.
  • Caciagli L; Department of Bioengineering, University of Pennsylvania, United States.
  • Hadar P; Department of Neurology, Massachusetts General Hospital, United States.
  • Gugger JJ; Department of Neurology, University of Pennsylvania, United States.
  • Das S; Department of Neurology, University of Pennsylvania, United States.
  • Stein JM; Department of Radiology, University of Pennsylvania, United States.
  • Davis KA; Department of Neurology, University of Pennsylvania, United States.
Neuroimage Clin ; 38: 103418, 2023.
Article en En | MEDLINE | ID: mdl-37187042
BACKGROUND AND MOTIVATION: Functional gradients have been used to study differences in connectivity between healthy and diseased brain states, however this work has largely focused on the cortex. Because the subcortex plays a key role in seizure initiation in temporal lobe epilepsy (TLE), subcortical functional-connectivity gradients may help further elucidate differences between healthy brains and TLE, as well as differences between left (L)-TLE and right (R)-TLE. METHODS: In this work, we calculated subcortical functional-connectivity gradients (SFGs) from resting-state functional MRI (rs-fMRI) by measuring the similarity in connectivity profiles of subcortical voxels to cortical gray matter voxels. We performed this analysis in 24 R-TLE patients and 31 L-TLE patients (who were otherwise matched for age, gender, disease specific characteristics, and other clinical variables), and 16 controls. To measure differences in SFGs between L-TLE and R-TLE, we quantified deviations in the average functional gradient distributions, as well as their variance, across subcortical structures. RESULTS: We found an expansion, measured by increased variance, in the principal SFG of TLE relative to controls. When comparing the gradient across subcortical structures between L-TLE and R-TLE, we found that abnormalities in the ipsilateral hippocampal gradient distributions were significantly different between L-TLE and R-TLE. CONCLUSION: Our results suggest that expansion of the SFG is characteristic of TLE. Subcortical functional gradient differences exist between left and right TLE and are driven by connectivity changes in the hippocampus ipsilateral to the seizure onset zone.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Epilepsia del Lóbulo Temporal Límite: Humans Idioma: En Revista: Neuroimage Clin Año: 2023 Tipo del documento: Article Pais de publicación: Países Bajos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Epilepsia del Lóbulo Temporal Límite: Humans Idioma: En Revista: Neuroimage Clin Año: 2023 Tipo del documento: Article Pais de publicación: Países Bajos