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Thyroid hormone regulates proximodistal patterning in fin rays.
Harper, Melody; Hu, Yinan; Donahue, Joan; Acosta, Benjamin; Dievenich Braes, Flora; Nguyen, Stacy; Zeng, Jenny; Barbaro, Julianna; Lee, Hyungwoo; Bui, Hoa; McMenamin, Sarah K.
Afiliación
  • Harper M; Biology Department, Morrissey College of Arts and Sciences, Boston College, Chestnut Hill, MA 02467.
  • Hu Y; Biology Department, Morrissey College of Arts and Sciences, Boston College, Chestnut Hill, MA 02467.
  • Donahue J; Biology Department, Morrissey College of Arts and Sciences, Boston College, Chestnut Hill, MA 02467.
  • Acosta B; Biology Department, Morrissey College of Arts and Sciences, Boston College, Chestnut Hill, MA 02467.
  • Dievenich Braes F; Biology Department, Morrissey College of Arts and Sciences, Boston College, Chestnut Hill, MA 02467.
  • Nguyen S; Biology Department, Morrissey College of Arts and Sciences, Boston College, Chestnut Hill, MA 02467.
  • Zeng J; Biology Department, Morrissey College of Arts and Sciences, Boston College, Chestnut Hill, MA 02467.
  • Barbaro J; Biology Department, Morrissey College of Arts and Sciences, Boston College, Chestnut Hill, MA 02467.
  • Lee H; Biology Department, Morrissey College of Arts and Sciences, Boston College, Chestnut Hill, MA 02467.
  • Bui H; Biology Department, Morrissey College of Arts and Sciences, Boston College, Chestnut Hill, MA 02467.
  • McMenamin SK; Biology Department, Morrissey College of Arts and Sciences, Boston College, Chestnut Hill, MA 02467.
Proc Natl Acad Sci U S A ; 120(21): e2219770120, 2023 05 23.
Article en En | MEDLINE | ID: mdl-37186843
Processes that regulate size and patterning along an axis must be highly integrated to generate robust shapes; relative changes in these processes underlie both congenital disease and evolutionary change. Fin length mutants in zebrafish have provided considerable insight into the pathways regulating fin size, yet signals underlying patterning have remained less clear. The bony rays of the fins possess distinct patterning along the proximodistal axis, reflected in the location of ray bifurcations and the lengths of ray segments, which show progressive shortening along the axis. Here, we show that thyroid hormone (TH) regulates aspects of proximodistal patterning of the caudal fin rays, regardless of fin size. TH promotes distal gene expression patterns, coordinating ray bifurcations and segment shortening with skeletal outgrowth along the proximodistal axis. This distalizing role for TH is conserved between development and regeneration, in all fins (paired and medial), and between Danio species as well as distantly related medaka. During regenerative outgrowth, TH acutely induces Shh-mediated skeletal bifurcation. Zebrafish have multiple nuclear TH receptors, and we found that unliganded Thrab-but not Thraa or Thrb-inhibits the formation of distal features. Broadly, these results demonstrate that proximodistal morphology is regulated independently from size-instructive signals. Modulating proximodistal patterning relative to size-either through changes to TH metabolism or other hormone-independent pathways-can shift skeletal patterning in ways that recapitulate aspects of fin ray diversity found in nature.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Pez Cebra / Proteínas de Pez Cebra Límite: Animals Idioma: En Revista: Proc Natl Acad Sci U S A Año: 2023 Tipo del documento: Article Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Pez Cebra / Proteínas de Pez Cebra Límite: Animals Idioma: En Revista: Proc Natl Acad Sci U S A Año: 2023 Tipo del documento: Article Pais de publicación: Estados Unidos