2',3'-seco pyrimidine nucleosides and nucleotides, including structural analogues of 3':5'-cyclic CMP and UMP, and their behaviour in several enzyme systems.
Biochem Biophys Res Commun
; 137(1): 453-60, 1986 May 29.
Article
en En
| MEDLINE
| ID: mdl-3718515
Cyclization of 2',3'-seco-5'- CMP and UMP with dicyclohexylcarbodiimide leads to 2',3'-seco-3':5'- cCMP and cUMP, formal structural analogues of 3':5'- cCMP and cUMP. POCl3 phosphorylation of 2',3'-secocytidine gave the same product in 50% yield, plus three additional seco nucleotides, one of which was independently obtained by enzymatic phosphorylation with the wheat shoot phosphotransferase system. The behaviour of these nucleotides has been examined in several enzyme systems. In particular, the seco 3':5'- cyclic phosphates are resistant to beef heart cyclic nucleotide phosphodiesterase, but are slowly hydrolyzed to the monophosphates by higher plant cyclic nucleotide phosphodiesterase.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Nucleótidos de Pirimidina
/
Ribonucleótidos
/
Nucleótidos Cíclicos
Límite:
Animals
Idioma:
En
Revista:
Biochem Biophys Res Commun
Año:
1986
Tipo del documento:
Article
Pais de publicación:
Estados Unidos