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The test-retest reliability of large and small fiber nerve excitability testing with threshold tracking.
Pia, Hossein; Nochi, Zahra; Kristensen, Alexander Gramm; Pelz, Bernhard; Goetz, Marcus; Hoeink, Jan-Niclas; Blockeel, Anthony James; Mouraux, André; Truini, Andrea; Finnerup, Nanna Brix; Phillips, Keith Geoffrey; Treede, Rolf-Detlef; Tankisi, Hatice.
Afiliación
  • Pia H; Department of Clinical Neurophysiology, Aarhus University Hospital, Denmark.
  • Nochi Z; Danish Pain Research Center, Department of Clinical Medicine, Aarhus University, Denmark.
  • Kristensen AG; Danish Pain Research Center, Department of Clinical Medicine, Aarhus University, Denmark.
  • Pelz B; Department of Clinical Neurophysiology, Aarhus University Hospital, Denmark.
  • Goetz M; Danish Pain Research Center, Department of Clinical Medicine, Aarhus University, Denmark.
  • Hoeink JN; MRC Systems GmbH, Heidelberg, Germany.
  • Blockeel AJ; MRC Systems GmbH, Heidelberg, Germany.
  • Mouraux A; MRC Systems GmbH, Heidelberg, Germany.
  • Truini A; School of Physiology, Pharmacology & Neuroscience, University of Bristol, United Kingdom.
  • Finnerup NB; Institute of Neuroscience (IoNS), UCLouvain, Brussels, Belgium.
  • Phillips KG; Department of Human Neuroscience, Sapienza University, Rome, Italy.
  • Treede RD; Danish Pain Research Center, Department of Clinical Medicine, Aarhus University, Denmark.
  • Tankisi H; Department of Neurology, Aarhus University Hospital, Aarhus, Denmark.
Clin Neurophysiol Pract ; 8: 71-78, 2023.
Article en En | MEDLINE | ID: mdl-37181417
Objective: Standard nerve excitability testing (NET) predominantly assesses Aα- and Aß-fiber function, but a method examining small afferents would be of great interest in pain studies. Here, we examined the properties of a novel perception threshold tracking (PTT) method that preferentially activates Aδ-fibers using weak currents delivered by a novel multipin electrode and compared its reliability with NET. Methods: Eighteen healthy subjects (mean age:34.06 ±â€¯2.0) were examined three times with motor and sensory NET and PTT in morning and afternoon sessions on the same day (intra-day reliability) and after a week (inter-day reliability). NET was performed on the median nerve, while PTT stimuli were delivered through a multipin electrode located on the forearm. During PTT, subjects indicated stimulus perception via a button press and the intensity of the current was automatically increased or decreased accordingly by Qtrac software. This allowed changes in the perception threshold to be tracked during strength-duration time constant (SDTC) and threshold electrotonus protocols. Results: The coefficient of variation (CoV) and interclass coefficient of variation (ICC) showed good-excellent reliability for most NET parameters. PTT showed poor reliability for both SDTC and threshold electrotonus parameters. There was a significant correlation between large (sensory NET) and small (PTT) fiber SDTC when all sessions were pooled (r = 0.29, p = 0.03). Conclusions: Threshold tracking technique can be applied directly to small fibers via a psychophysical readout, but with the current technique, the reliability is poor. Significance: Further studies are needed to examine whether Aß-fiber SDTC may be a surrogate biomarker for peripheral nociceptive signalling.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Clin Neurophysiol Pract Año: 2023 Tipo del documento: Article País de afiliación: Dinamarca Pais de publicación: Países Bajos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Clin Neurophysiol Pract Año: 2023 Tipo del documento: Article País de afiliación: Dinamarca Pais de publicación: Países Bajos