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Left atrial appendage strain predicts subclinical atrial fibrillation in embolic strokes of undetermined source.
Saberniak, Jørg; Skrebelyte-Strøm, Loreta; Orstad, Eivind Bjørkan; Hilde, Janne Mykland; Solberg, Magnar Gangås; Rønning, Ole Morten; Kjekshus, Harald; Steine, Kjetil.
Afiliación
  • Saberniak J; Department of Cardiology, Division of Medicine, Akershus University Hospital, Sykehusveien 25, 1474 Nordbyhagen, PO box 1000, Lørenskog 1478, Norway.
  • Skrebelyte-Strøm L; Department of Cardiology, Division of Medicine, Akershus University Hospital, Sykehusveien 25, 1474 Nordbyhagen, PO box 1000, Lørenskog 1478, Norway.
  • Orstad EB; Department of Neurology, Akershus University Hospital, Lørenskog, Norway.
  • Hilde JM; Faculty of Medicine, University of Oslo, Oslo, Norway.
  • Solberg MG; Department of Cardiology, Division of Medicine, Akershus University Hospital, Sykehusveien 25, 1474 Nordbyhagen, PO box 1000, Lørenskog 1478, Norway.
  • Rønning OM; Department of Cardiology, Division of Medicine, Akershus University Hospital, Sykehusveien 25, 1474 Nordbyhagen, PO box 1000, Lørenskog 1478, Norway.
  • Kjekshus H; Faculty of Medicine, University of Oslo, Oslo, Norway.
  • Steine K; Department of Medical Research, Bærum Hospital, Vestre Viken Hospital Trust, Gjettum, Norway.
Eur Heart J Open ; 3(3): oead039, 2023 May.
Article en En | MEDLINE | ID: mdl-37180468
Aims: Left atrial (LA) strain is promising in prediction of clinical atrial fibrillation (AF) in stroke patients. However, prediction of subclinical AF is critical in patients with embolic strokes of undetermined source (ESUS). The aim of this prospective study was to investigate novel LA and left atrial appendage (LAA) strain markers in prediction of subclinical AF in ESUS patients. Methods and results: A total of 185 patients with ESUS, mean age 68 ± 13years, 33% female, without diagnosed AF, were included. LAA and LA function by conventional echocardiographic parameters and reservoir strain (Sr), conduit strain (Scd), contraction strain (Sct), and mechanical dispersion (MD) of Sr were assessed with transoesophageal and transthoracic echocardiography. Subclinical AF was detected by insertable cardiac monitors during follow-up. LAA strain was impaired in 60 (32%) patients with subclinical AF compared to those with sinus rhythm: LAA-Sr, 19.2 ± 4.5% vs. 25.6 ± 6.5% (P < 0.001); LAA-Scd, -11.0 ± 3.1% vs. -14.4 ± 4.5% (P < 0.001); and LAA-Sct, -7.9 ± 4.0% vs. -11.2 ± 4% (P < 0.001), respectively, while LAA-MD was increased, 34 ± 24 ms vs. 26 ± 20 ms (P = 0.02). However, there was no significant difference in phasic LA strain or LA-MD. By ROC analyses, LAA-Sr was highly significant in prediction of subclinical AF and showed the best AUC of 0.80 (95% CI 0.73-0.87) with a sensitivity of 80% and a specificity of 73% (P < 0.001). LAA-Sr and LAA-MD were both independent and incremental markers of subclinical AF in ESUS patients. Conclusion: LAA function by strain and mechanical dispersion predicted subclinical AF in ESUS patients. These novel echocardiographic markers may improve risk stratification in ESUS patients.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Observational_studies / Prognostic_studies / Risk_factors_studies Idioma: En Revista: Eur Heart J Open Año: 2023 Tipo del documento: Article País de afiliación: Noruega Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Observational_studies / Prognostic_studies / Risk_factors_studies Idioma: En Revista: Eur Heart J Open Año: 2023 Tipo del documento: Article País de afiliación: Noruega Pais de publicación: Reino Unido