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Aqueous Humor Cytokine Profile in Primary Congenital Glaucoma.
Oribio-Quinto, Carlos; Burgos-Blasco, Barbara; Pérez-García, Pilar; Espino-Paisán, Laura; Sarriá, Beatriz; Fernández-Vigo, José Ignacio; García-Feijóo, Julian.
Afiliación
  • Oribio-Quinto C; Ophthalmology Department, Hospital Clínico San Carlos, Institute of Health Research (IdISSC), 28040 Madrid, Spain.
  • Burgos-Blasco B; Ophthalmology Department, Hospital Clínico San Carlos, Institute of Health Research (IdISSC), 28040 Madrid, Spain.
  • Pérez-García P; Ophthalmology Department, Hospital Clínico San Carlos, Institute of Health Research (IdISSC), 28040 Madrid, Spain.
  • Espino-Paisán L; Laboratorio de Investigación en Genética de Enfermedades Complejas, Instituto de Investigación Sanitaria del Hospital Clínico San Carlos (IdISSC), 28040 Madrid, Spain.
  • Sarriá B; Department of Metabolism and Nutrition, Institute of Food Science, Technology and Nutrition (ICTAN), Spanish National Research Council (CSIC), 28040 Madrid, Spain.
  • Fernández-Vigo JI; Ophthalmology Department, Hospital Clínico San Carlos, Institute of Health Research (IdISSC), 28040 Madrid, Spain.
  • García-Feijóo J; Ophthalmology Department, Hospital Clínico San Carlos, Institute of Health Research (IdISSC), 28040 Madrid, Spain.
J Clin Med ; 12(9)2023 Apr 26.
Article en En | MEDLINE | ID: mdl-37176583
BACKGROUND: Cytokine profile in patients with primary open-angle glaucoma (POAG) differs from that in healthy controls. Due to the different pathophysiological mechanisms involved in the genesis of primary congenital glaucoma (PCG) and POAG, it is possible that the cytokine profile could also differ. The main objective of this study was to compare the concentrations of cytokines in the aqueous humor of patients with PCG with those of POAG patients and a control group. METHODS: A cross-sectional study was conducted. Aqueous humor samples were taken from PCG and POAG patients eligible for glaucoma or cataract surgery and from patients undergoing cataract surgery. Twenty-seven cytokines were analyzed using the Human Cytokine 27-Plex Immunoassay Kit (Bio-Rad Laboratories, Hercules, CA, USA). RESULTS: A total of 107 subjects were included: patients with PCG (n = 19), patients with POAG (n = 54), and a control group (CG) of patients undergoing cataract surgery (n = 34). Most cytokines measured in aqueous humor in PCG presented decreased values compared with POAG and controls. A statistically significant difference was observed in IL-1ra, IL-2, IL-5, IL-7, IL-8, IL-10, IL-12, IL-15, IL-17A, Eotaxin, FGF basic, G-CSF, GM-CSF, IFN-γ, MIP-1α, PDGF-bb, MIP-1ß, RANTES, TNF-α, and VEGF. CONCLUSION: PCG patients have a cytokine profile in aqueous humor different from POAG patients and patients without glaucoma, characterized by lower concentrations of multiple cytokines.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Observational_studies Idioma: En Revista: J Clin Med Año: 2023 Tipo del documento: Article País de afiliación: España Pais de publicación: Suiza
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Observational_studies Idioma: En Revista: J Clin Med Año: 2023 Tipo del documento: Article País de afiliación: España Pais de publicación: Suiza