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Impact of Single Hemodialysis Treatment on immune Cell Subpopulations.
Donadei, Chiara; Angeletti, Andrea; Pizzuti, Valeria; Zappulo, Fulvia; Conte, Diletta; Cappuccilli, Maria; Chiocchini, Anna Laura; Scrivo, Anna; Apuzzo, Delia; Mariggiò, Maria Addolorata; Gasperoni, Lorenzo; Donati, Gabriele; La Manna, Gaetano.
Afiliación
  • Donadei C; Nephrology, Dialysis and Renal Transplant Unit, IRCCS-Azienda Ospedaliero-Universitaria di Bologna, 40139 Bologna, Italy.
  • Angeletti A; Division of Nephrology, Dialysis and Transplantation, IRCCS Istituto Giannina Gaslini, Genoa Largo Gaslini, 16148 Genoa, Italy.
  • Pizzuti V; Department of Medical and Surgical Sciences (DIMEC), University of Bologna, 40126 Bologna, Italy.
  • Zappulo F; Nephrology, Dialysis and Renal Transplant Unit, IRCCS-Azienda Ospedaliero-Universitaria di Bologna, 40139 Bologna, Italy.
  • Conte D; Department of Medical and Surgical Sciences (DIMEC), University of Bologna, 40126 Bologna, Italy.
  • Cappuccilli M; Department of Medical and Surgical Sciences (DIMEC), University of Bologna, 40126 Bologna, Italy.
  • Chiocchini AL; Nephrology, Dialysis and Renal Transplant Unit, IRCCS-Azienda Ospedaliero-Universitaria di Bologna, 40139 Bologna, Italy.
  • Scrivo A; Nephrology, Dialysis and Renal Transplant Unit, IRCCS-Azienda Ospedaliero-Universitaria di Bologna, 40139 Bologna, Italy.
  • Apuzzo D; Nephrology, Dialysis and Renal Transplant Unit, IRCCS-Azienda Ospedaliero-Universitaria di Bologna, 40139 Bologna, Italy.
  • Mariggiò MA; Department of Precision and Regenerative Medicine and Area Jonica, School of Medicine, University of Bari, 70121 Bari, Italy.
  • Gasperoni L; Nephrology, Dialysis and Renal Transplant Unit, IRCCS-Azienda Ospedaliero-Universitaria di Bologna, 40139 Bologna, Italy.
  • Donati G; Nephrology and Dialysis Unit, Infermi Hospital, AUSL Romagna, 47923 Rimini, Italy.
  • La Manna G; Nephrology, Dialysis and Renal Transplant Unit, Azienda Ospedaliero Universitaria di Modena, 41124 Modena, Italy.
J Clin Med ; 12(9)2023 Apr 25.
Article en En | MEDLINE | ID: mdl-37176548
Hemodialysis (HD) is known to trigger a chronic inflammatory status, affecting the innate and acquired immune response. This study was aimed at a comparative analysis of immune cell subsets, proliferation, and apoptosis in subjects receiving chronic HD treatment with respect to a healthy control. Regardless of the dialysis filter used, we observed a reshaping of the acquired immune component both with respect to healthy patients and between the various sessions of dialysis treatment, with an impairment of CD3 cells, along with an increase in CD4 and CD8 cell populations producing pro-inflammatory factors such as IL-17 and IFN-gamma. The population of B cells, monocytes and NK cells were not impaired by the dialysis procedure. These results confirmed the high impact of the HD treatment on the patient's immune system, underlying the imbalance of T cell counterparts.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: J Clin Med Año: 2023 Tipo del documento: Article País de afiliación: Italia Pais de publicación: Suiza
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: J Clin Med Año: 2023 Tipo del documento: Article País de afiliación: Italia Pais de publicación: Suiza