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The Synthesis and Biological Activity of Organotin Complexes with Thio-Schiff Bases Bearing Phenol Fragments.
Smolyaninov, Ivan V; Poddel'sky, Andrey I; Burmistrova, Daria A; Voronina, Yulia K; Pomortseva, Nadezhda P; Polovinkina, Maria A; Almyasheva, Nailya R; Zamkova, Maria A; Berberova, Nadezhda T; Eremenko, Igor L.
Afiliación
  • Smolyaninov IV; Chemistry Department, Astrakhan State Technical University, 16 Tatisheva Str., 414056 Astrakhan, Russia.
  • Poddel'sky AI; Chemistry Department, University of Tübingen, Auf der Morgenstelle 18, 72076 Tübingen, Germany.
  • Burmistrova DA; Chemistry Department, Astrakhan State Technical University, 16 Tatisheva Str., 414056 Astrakhan, Russia.
  • Voronina YK; Kurnakov Institute of General and Inorganic Chemistry, Russian Academy of Sciences, Leninskii Prospekt 31, 119071 Moscow, Russia.
  • Pomortseva NP; Chemistry Department, Astrakhan State Technical University, 16 Tatisheva Str., 414056 Astrakhan, Russia.
  • Polovinkina MA; Toxicology Research Group of Southern Scientific Centre of Russian Academy of Science, 41 Chekhova Str., 344006 Rostov-on-Don, Russia.
  • Almyasheva NR; Gause Institute of New Antibiotics, 11/1 Bolshaya Pirogovskaya Str., 119021 Moscow, Russia.
  • Zamkova MA; N.N. Blokhin National Medical Research Center of Oncology, Ministry of Health of the Russian Federation, Kashirskoe sh., 24, 115478 Moscow, Russia.
  • Berberova NT; Chemistry Department, Astrakhan State Technical University, 16 Tatisheva Str., 414056 Astrakhan, Russia.
  • Eremenko IL; Kurnakov Institute of General and Inorganic Chemistry, Russian Academy of Sciences, Leninskii Prospekt 31, 119071 Moscow, Russia.
Int J Mol Sci ; 24(9)2023 May 05.
Article en En | MEDLINE | ID: mdl-37176027
A number of novel di- and triorganotin(IV) complexes 1-5 (Ph2SnL1, Ph2SnL2, Et2SnL2, Ph3SnL3, Ph3SnL4) with mono- or dianionic forms of thio-Schiff bases containing antioxidant sterically hindered phenol or catechol fragments were synthesized. Compounds 1-5 were characterized by 1H, 13C NMR, IR spectroscopy, and elemental analysis. The molecular structures of complexes 1 and 2 in the crystal state were established by single-crystal X-ray analysis. The antioxidant activity of new complexes as radical scavengers was estimated in DPPH and ABTS assays. It was found that compounds 4 and 5 with free phenol or catechol fragments are more active in these tests than complexes 1-3 with tridentate O,N,S-coordinated ligands. The effect of compounds 1-5 on the promoted oxidative damage of the DNA by 2,2'-azobis(2-amidinopropane) dihydrochloride and in the process of rat liver (Wistar) homogenate lipid peroxidation in vitro was determined. Complexes 4 and 5 were characterized by more pronounced antioxidant activity in the reaction of lipid peroxidation in vitro than compounds 1-3. The antiproliferative activity of compounds 1-5 was investigated against MCF-7, HTC-116, and A-549 cell lines by an MTT test. The values of IC50 are significantly affected by the presence of free antioxidant fragments and the coordination site for binding.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Compuestos Orgánicos de Estaño / Complejos de Coordinación Límite: Animals Idioma: En Revista: Int J Mol Sci Año: 2023 Tipo del documento: Article País de afiliación: Rusia Pais de publicación: Suiza
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Compuestos Orgánicos de Estaño / Complejos de Coordinación Límite: Animals Idioma: En Revista: Int J Mol Sci Año: 2023 Tipo del documento: Article País de afiliación: Rusia Pais de publicación: Suiza