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Enantioselective Labeling of Zebrafish for D-Phenylalanine Based on Graphene-Based Nanoplatform.
He, Yuqing; Ye, Ziqi; Zhu, Fei; Qiu, Tianxiang; Dai, Xiyan; Xie, Yue; Zou, Shibiao; Dong, Qingjian; Zhang, Weiying; Ma, Junkai; Mao, Xiaowei.
Afiliación
  • He Y; Hubei Key Laboratory of Environmental and Health Effects of Persistent Toxic Substances, School of Environment and Health, Jianghan University, Wuhan 430056, China.
  • Ye Z; Key Laboratory of Optoelectronic Chemical Materials and Devices of Ministry of Education, School of Life Science, Jianghan University, Wuhan 430056, China.
  • Zhu F; Hubei Key Laboratory of Embryonic Stem Cell Research, School of Basic Medical Science, Hubei University of Medicine, Shiyan 442000, China.
  • Qiu T; Hubei Key Laboratory of Environmental and Health Effects of Persistent Toxic Substances, School of Environment and Health, Jianghan University, Wuhan 430056, China.
  • Dai X; Hubei Key Laboratory of Environmental and Health Effects of Persistent Toxic Substances, School of Environment and Health, Jianghan University, Wuhan 430056, China.
  • Xie Y; Hubei Key Laboratory of Environmental and Health Effects of Persistent Toxic Substances, School of Environment and Health, Jianghan University, Wuhan 430056, China.
  • Zou S; Hubei Key Laboratory of Environmental and Health Effects of Persistent Toxic Substances, School of Environment and Health, Jianghan University, Wuhan 430056, China.
  • Dong Q; Department of Nuclear Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.
  • Zhang W; Key Laboratory of Optoelectronic Chemical Materials and Devices of Ministry of Education, School of Life Science, Jianghan University, Wuhan 430056, China.
  • Ma J; Hubei Key Laboratory of Wudang Local Chinese Medicine Research, Department of Chemistry, School of Pharmacy, Hubei University of Medicine, Shiyan 442000, China.
  • Mao X; Hubei Key Laboratory of Environmental and Health Effects of Persistent Toxic Substances, School of Environment and Health, Jianghan University, Wuhan 430056, China.
Molecules ; 28(9)2023 Apr 25.
Article en En | MEDLINE | ID: mdl-37175110
Enantioselective labeling of important bioactive molecules in complex biological environments by artificial receptors has drawn great interest. From both the slight difference of enantiomers' physicochemical properties and inherently complexity in living organism point of view, it is still a contemporary challenge for preparing practical chiral device that could be employed in the model animal due to diverse biological interference. Herein, we introduce γ-cyclodextrin onto graphene oxide for fabricating γ-cyclodextrin and graphene oxide assemblies, which provided an efficient nanoplatform for chiral labelling of D-phenylalanine with higher chiral discrimination ratio of KD/KL = 8.21. Significantly, the chiral fluorescence quenching effect of this γ-CD-GO nanoplatform for D-phenylalanine enantiomer in zebrafish was 7.0-fold higher than L-isomer, which exhibiting real promise for producing practical enantio-differentiating graphene-based systems in a complex biological sample.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Gamma-Ciclodextrinas / Grafito Límite: Animals Idioma: En Revista: Molecules Asunto de la revista: BIOLOGIA Año: 2023 Tipo del documento: Article País de afiliación: China Pais de publicación: Suiza
Texto completo
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Imprimir
XML
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Gamma-Ciclodextrinas / Grafito Límite: Animals Idioma: En Revista: Molecules Asunto de la revista: BIOLOGIA Año: 2023 Tipo del documento: Article País de afiliación: China Pais de publicación: Suiza