Your browser doesn't support javascript.
loading
Levamisole derivatives as immune modulators for the treatment of amyotrophic lateral sclerosis (ALS).
Baugh, Simon Dp; Morrice, Jessica R; Reitz, Allen B; Shaw, Christopher A; Gregory-Evans, Cheryl Y.
Afiliación
  • Baugh SD; Fox Chase Therapeutics Discovery, Inc., Doylestown, PA 18902, USA.
  • Morrice JR; Department of Ophthalmology, University of British Columbia, Vancouver, BC, V5Z 3N9, Canada.
  • Reitz AB; Fox Chase Therapeutics Discovery, Inc., Doylestown, PA 18902, USA.
  • Shaw CA; Department of Ophthalmology, University of British Columbia, Vancouver, BC, V5Z 3N9, Canada.
  • Gregory-Evans CY; Department of Ophthalmology, University of British Columbia, Vancouver, BC, V5Z 3N9, Canada.
Future Med Chem ; 15(8): 651-659, 2023 04.
Article en En | MEDLINE | ID: mdl-37170865
Aim: To discover derivatives of the antiparasitic worm drug levamisole, which has been reported to be able to modulate the immune response, as treatments for amyotrophic lateral sclerosis (ALS), which has been suggested to be in part an autoimmune disease. Results: We have synthesized ten analogs of a variation of levamisole, tetramisole, as well as 11 analogs on a related system. All of the analogs have been tested for their ability to affect the response of five ALS-relevant immune-modulatory substances (cytokines). Conclusion: We have discovered a number of interesting derivatives that have encouraging cytokine response data and good metabolic stability, with the potential to have a positive impact on ALS either as single agents, or in combination.
Asunto(s)
Palabras clave
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Esclerosis Amiotrófica Lateral Límite: Humans Idioma: En Revista: Future Med Chem Año: 2023 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Esclerosis Amiotrófica Lateral Límite: Humans Idioma: En Revista: Future Med Chem Año: 2023 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Reino Unido