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Structure-Activity Relationships of Flupirtine Analogues for Liver Esterase-Mediated Cleavage of the 4-Fluorobenzylamine Moiety and Its Possible Relevance to Liver Toxicity.
Beirow, Kristin; Jedamzik, Julia; Schulig, Lukas; Wurm, Konrad W; Lemmerhirt, Christian J; Hofstetter, Robert K; Link, Andreas; Bednarski, Patrick J.
Afiliación
  • Beirow K; Department of Pharmaceutical/Medicinal Chemistry Institute of Pharmacy, University of Greifswald, Friedrich-Ludwig-Jahn-Str. 17, 17489, Greifswald, Germany.
  • Jedamzik J; Department of Pharmaceutical/Medicinal Chemistry Institute of Pharmacy, University of Greifswald, Friedrich-Ludwig-Jahn-Str. 17, 17489, Greifswald, Germany.
  • Schulig L; Department of Pharmaceutical/Medicinal Chemistry Institute of Pharmacy, University of Greifswald, Friedrich-Ludwig-Jahn-Str. 17, 17489, Greifswald, Germany.
  • Wurm KW; Department of Pharmaceutical/Medicinal Chemistry Institute of Pharmacy, University of Greifswald, Friedrich-Ludwig-Jahn-Str. 17, 17489, Greifswald, Germany.
  • Lemmerhirt CJ; Department of Pharmaceutical/Medicinal Chemistry Institute of Pharmacy, University of Greifswald, Friedrich-Ludwig-Jahn-Str. 17, 17489, Greifswald, Germany.
  • Hofstetter RK; Department of Pharmaceutical/Medicinal Chemistry Institute of Pharmacy, University of Greifswald, Friedrich-Ludwig-Jahn-Str. 17, 17489, Greifswald, Germany.
  • Link A; Present address: Department of Pharmaceutical/Medicinal Chemistry Institute of Pharmacy, Friedrich-Schiller-University Jena, Philosophenweg 14, 07743, Jena, Germany.
  • Bednarski PJ; Department of Pharmaceutical/Medicinal Chemistry Institute of Pharmacy, University of Greifswald, Friedrich-Ludwig-Jahn-Str. 17, 17489, Greifswald, Germany.
ChemMedChem ; 18(14): e202300145, 2023 07 17.
Article en En | MEDLINE | ID: mdl-37170841
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Esterasas / Enfermedad Hepática Inducida por Sustancias y Drogas Límite: Humans Idioma: En Revista: ChemMedChem Asunto de la revista: FARMACOLOGIA / QUIMICA Año: 2023 Tipo del documento: Article País de afiliación: Alemania Pais de publicación: Alemania
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Esterasas / Enfermedad Hepática Inducida por Sustancias y Drogas Límite: Humans Idioma: En Revista: ChemMedChem Asunto de la revista: FARMACOLOGIA / QUIMICA Año: 2023 Tipo del documento: Article País de afiliación: Alemania Pais de publicación: Alemania