Structural insights into DarT toxin neutralization by cognate DarG antitoxin: ssDNA mimicry by DarG C-terminal domain keeps the DarT toxin inhibited.

Deep, Amar; Singh, Latika; Kaur, Japleen; Velusamy, Maheshwaran; Bhardwaj, Pushpanjali; Singh, Ramandeep; Thakur, Krishan Gopal

Deep, Amar; Singh, Latika; Kaur, Japleen; Velusamy, Maheshwaran; Bhardwaj, Pushpanjali; Singh, Ramandeep; Thakur, Krishan Gopal.

Afiliación

Deep A; Structural Biology Laboratory, Council of Scientific and Industrial Research-Institute of Microbial Technology (CSIR-IMTECH), Chandigarh 160036, India.
Singh L; Structural Biology Laboratory, Council of Scientific and Industrial Research-Institute of Microbial Technology (CSIR-IMTECH), Chandigarh 160036, India.
Kaur J; Structural Biology Laboratory, Council of Scientific and Industrial Research-Institute of Microbial Technology (CSIR-IMTECH), Chandigarh 160036, India.
Velusamy M; Structural Biology Laboratory, Council of Scientific and Industrial Research-Institute of Microbial Technology (CSIR-IMTECH), Chandigarh 160036, India.
Bhardwaj P; Structural Biology Laboratory, Council of Scientific and Industrial Research-Institute of Microbial Technology (CSIR-IMTECH), Chandigarh 160036, India.
Singh R; Infection and Immunology Group, Tuberculosis Research Laboratory, Translational Health Science and Technology Institute, NCR-Biotech Science Cluster, 3rd Milestone, Faridabad Gurugram Expressway, Faridabad-121001, India.
Thakur KG; Structural Biology Laboratory, Council of Scientific and Industrial Research-Institute of Microbial Technology (CSIR-IMTECH), Chandigarh 160036, India. Electronic address: krishang@imtech.res.in.

Structure ; 31(7): 780-789.e4, 2023 07 06.

Article en En | MEDLINE | ID: mdl-37167974

Asunto(s)

Antitoxinas; Toxinas Bacterianas; Antitoxinas/química; ADN de Cadena Simple; Toxinas Bacterianas/química; Modelos Moleculares; Proteínas Bacterianas/química

Palabras clave

DNA mimic; DNA modification; DNA ribosylation; DarTG; Mycobacterium tuberculosis; toxin-antitoxin system; toxin-binding domain

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Toxinas Bacterianas / Antitoxinas Idioma: En Revista: Structure Asunto de la revista: BIOLOGIA MOLECULAR / BIOQUIMICA / BIOTECNOLOGIA Año: 2023 Tipo del documento: Article País de afiliación: India Pais de publicación: Estados Unidos

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