Influence of amino acid size at the P3 position of N-Cbz-tripeptide Michael acceptors targeting falcipain-2 and rhodesain for the treatment of malaria and human african trypanosomiasis.

Previti, Santo; Ettari, Roberta; Di Chio, Carla; Legac, Jenny; Bogacz, Marta; Zimmer, Collin; Schirmeister, Tanja; Rosenthal, Philip J; Zappalà, Maria

Previti, Santo; Ettari, Roberta; Di Chio, Carla; Legac, Jenny; Bogacz, Marta; Zimmer, Collin; Schirmeister, Tanja; Rosenthal, Philip J; Zappalà, Maria.

Afiliación

Previti S; Department of Chemical, Biological, Pharmaceutical, and Environmental Sciences, University of Messina, Viale Stagno d'Alcontres 31, 98166 Messina, Italy. Electronic address: spreviti@unime.it.
Ettari R; Department of Chemical, Biological, Pharmaceutical, and Environmental Sciences, University of Messina, Viale Stagno d'Alcontres 31, 98166 Messina, Italy.
Di Chio C; Department of Chemical, Biological, Pharmaceutical, and Environmental Sciences, University of Messina, Viale Stagno d'Alcontres 31, 98166 Messina, Italy.
Legac J; Department of Medicine, University of California, San Francisco, CA 94143, United States.
Bogacz M; Institute of Organic Chemistry & Macromolecular Chemistry, Friedrich-Schiller-University of Jena, 07743 Jena, Germany.
Zimmer C; Institute of Pharmaceutical and Biomedical Sciences, University of Mainz, 55128 Mainz, Germany.
Schirmeister T; Institute of Pharmaceutical and Biomedical Sciences, University of Mainz, 55128 Mainz, Germany.
Rosenthal PJ; Department of Medicine, University of California, San Francisco, CA 94143, United States.
Zappalà M; Department of Chemical, Biological, Pharmaceutical, and Environmental Sciences, University of Messina, Viale Stagno d'Alcontres 31, 98166 Messina, Italy.

Bioorg Chem ; 137: 106587, 2023 08.

Article en En | MEDLINE | ID: mdl-37163812

Asunto(s)

Malaria Falciparum; Malaria; Tripanosomiasis Africana; Animales; Humanos; Tripanosomiasis Africana/tratamiento farmacológico; Aminoácidos; Malaria Falciparum/tratamiento farmacológico; Plasmodium falciparum; Relación Estructura-Actividad

Palabras clave

Antimalarial; Antitrypanosomal; Falcipain-2; Michael acceptors; Neglected tropical diseases; Protozoan cysteine proteases; Rhodesain

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Tripanosomiasis Africana / Malaria Falciparum / Malaria Límite: Animals / Humans Idioma: En Revista: Bioorg Chem Año: 2023 Tipo del documento: Article Pais de publicación: Estados Unidos

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