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Antitumor efficacy of multi-target in situ vaccinations with CpG oligodeoxynucleotides, anti-OX40, anti-PD1 antibodies, and aptamers.
Proskurina, Anastasia S; Ruzanova, Vera S; Ritter, Genrikh S; Efremov, Yaroslav R; Mustafin, Zakhar S; Lashin, Sergey A; Burakova, Ekaterina A; Fokina, Alesya A; Zatsepin, Timofei S; Stetsenko, Dmitry A; Leplina, Olga Y; Ostanin, Alexandr A; Chernykh, Elena R; Bogachev, Sergey S.
Afiliación
  • Proskurina AS; Institute of Cytology and Genetics, Siberian Branch of the Russian Academy of Sciences, Novosibirsk 630090, Russia.
  • Ruzanova VS; Institute of Cytology and Genetics, Siberian Branch of the Russian Academy of Sciences, Novosibirsk 630090, Russia.
  • Ritter GS; Institute of Cytology and Genetics, Siberian Branch of the Russian Academy of Sciences, Novosibirsk 630090, Russia.
  • Efremov YR; Institute of Cytology and Genetics, Siberian Branch of the Russian Academy of Sciences, Novosibirsk 630090, Russia.
  • Mustafin ZS; Department of Natural Sciences, Novosibirsk State University, Novosibirsk 630090, Russia.
  • Lashin SA; Institute of Cytology and Genetics, Siberian Branch of the Russian Academy of Sciences, Novosibirsk 630090, Russia.
  • Burakova EA; Institute of Cytology and Genetics, Siberian Branch of the Russian Academy of Sciences, Novosibirsk 630090, Russia.
  • Fokina AA; Department of Natural Sciences, Novosibirsk State University, Novosibirsk 630090, Russia.
  • Zatsepin TS; Institute of Cytology and Genetics, Siberian Branch of the Russian Academy of Sciences, Novosibirsk 630090, Russia.
  • Stetsenko DA; Department of Physics, Novosibirsk State University, Novosibirsk 630090, Russia.
  • Leplina OY; Institute of Cytology and Genetics, Siberian Branch of the Russian Academy of Sciences, Novosibirsk 630090, Russia.
  • Ostanin AA; Department of Physics, Novosibirsk State University, Novosibirsk 630090, Russia.
  • Chernykh ER; Department of Chemistry, Moscow State University, Moscow 119991, Russia.
  • Bogachev SS; Institute of Cytology and Genetics, Siberian Branch of the Russian Academy of Sciences, Novosibirsk 630090, Russia.
J Biomed Res ; 37(3): 194-212, 2022 Nov 28.
Article en En | MEDLINE | ID: mdl-37161885
To overcome immune tolerance to cancer, the immune system needs to be exposed to a multi-target action intervention. Here, we investigated the activating effect of CpG oligodeoxynucleotides (ODNs), mesyl phosphoramidate CpG ODNs, anti-OX40 antibodies, and OX40 RNA aptamers on major populations of immunocompetent cells ex vivo. Comparative analysis of the antitumor effects of in situ vaccination with CpG ODNs and anti-OX40 antibodies, as well as several other combinations, such as mesyl phosphoramidate CpG ODNs and OX40 RNA aptamers, was conducted. Antibodies against programmed death 1 (PD1) checkpoint inhibitors or their corresponding PD1 DNA aptamers were also added to vaccination regimens for analytical purposes. Four scenarios were considered: a weakly immunogenic Krebs-2 carcinoma grafted in CBA mice; a moderately immunogenic Lewis carcinoma grafted in C57Black/6 mice; and an immunogenic A20 B cell lymphoma or an Ehrlich carcinoma grafted in BALB/c mice. Adding anti-PD1 antibodies (CpG+αOX40+αPD1) to in situ vaccinations boosts the antitumor effect. When to be used instead of antibodies, aptamers also possess antitumor activity, although this effect was less pronounced. The strongest effect across all the tumors was observed in highly immunogenic A20 B cell lymphoma and Ehrlich carcinoma.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: J Biomed Res Año: 2022 Tipo del documento: Article País de afiliación: Rusia Pais de publicación: China
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: J Biomed Res Año: 2022 Tipo del documento: Article País de afiliación: Rusia Pais de publicación: China