Your browser doesn't support javascript.
loading
Enhanced late positive potential to conditioned threat cue during delayed extinction in anxious youth.
Klein, Zohar; Shner-Livne, Gil; Danon-Kraun, Shani; Ginat-Frolich, Rivkah; Pine, Daniel S; Shechner, Tomer.
Afiliación
  • Klein Z; School of Psychological Sciences and the Integrated Brain and Behavior Research Center, University of Haifa, Haifa, Israel.
  • Shner-Livne G; School of Psychological Sciences and the Integrated Brain and Behavior Research Center, University of Haifa, Haifa, Israel.
  • Danon-Kraun S; School of Psychological Sciences and the Integrated Brain and Behavior Research Center, University of Haifa, Haifa, Israel.
  • Ginat-Frolich R; School of Psychological Sciences and the Integrated Brain and Behavior Research Center, University of Haifa, Haifa, Israel.
  • Pine DS; National Institute of Mental Health (NIMH), National Institutes of Health (NIH), Bethesda, MD, USA.
  • Shechner T; School of Psychological Sciences and the Integrated Brain and Behavior Research Center, University of Haifa, Haifa, Israel.
J Child Psychol Psychiatry ; 65(2): 215-228, 2024 Feb.
Article en En | MEDLINE | ID: mdl-37157184
BACKGROUND: Deficits in threat learning relate to anxiety symptoms. Since several anxiety disorders arise in adolescence, impaired adolescent threat learning could contribute to adolescent changes in risk for anxiety. This study compared threat learning among anxious and non-anxious youth using self-reports, peripheral psychophysiology measures, and event-related potentials. Because exposure therapy, the first-line treatment for anxiety disorders, is largely based on principles of extinction learning, the study also examined the link between extinction learning and treatment outcomes among anxious youth. METHODS: Clinically anxious (n = 28) and non-anxious (n = 33) youth completed differential threat acquisition and immediate extinction. They returned to the lab a week later to complete a threat generalization test and a delayed extinction task. Following these two experimental visits, anxious youth received exposure therapy for 12 weeks. RESULTS: Anxious as compared to non-anxious youth demonstrated elevated cognitive and physiological responses across acquisition and immediate extinction learning, as well as greater threat generalization. In addition, anxious youth showed enhanced late positive potential response to the conditioned threat cue compared to the safety cue during delayed extinction. Finally, aberrant neural response during delayed extinction was associated with poorer treatment outcomes. CONCLUSIONS: The study emphasizes differences between anxious and non-anxious youth in threat learning processes and provides preliminary support for a link between neural processing during delayed extinction and exposure-based treatment outcome in pediatric anxiety.
Asunto(s)
Palabras clave
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Extinción Psicológica / Miedo Límite: Adolescent / Child / Humans Idioma: En Revista: J Child Psychol Psychiatry Año: 2024 Tipo del documento: Article País de afiliación: Israel Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Extinción Psicológica / Miedo Límite: Adolescent / Child / Humans Idioma: En Revista: J Child Psychol Psychiatry Año: 2024 Tipo del documento: Article País de afiliación: Israel Pais de publicación: Reino Unido