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Strategic outline of interventions targeting extracellular matrix for promoting healthy longevity.
Park, Ji Young Cecilia; King, Aaron; Björk, Victor; English, Bradley W; Fedintsev, Alexander; Ewald, Collin Y.
Afiliación
  • Park JYC; Laboratory of Extracellular Matrix Regeneration, Institute of Translational Medicine, Department of Health Sciences and Technology, ETH Zürich, Schwerzenbach, Switzerland.
  • King A; Foresight Institute, San Francisco, California, United States.
  • Björk V; Heales VZW, Brussels, Belgium.
  • English BW; Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, United States.
  • Fedintsev A; Radical Life Extension Group, Alicante, Spain.
  • Ewald CY; Laboratory of Extracellular Matrix Regeneration, Institute of Translational Medicine, Department of Health Sciences and Technology, ETH Zürich, Schwerzenbach, Switzerland.
Am J Physiol Cell Physiol ; 325(1): C90-C128, 2023 07 01.
Article en En | MEDLINE | ID: mdl-37154490
The extracellular matrix (ECM), composed of interlinked proteins outside of cells, is an important component of the human body that helps maintain tissue architecture and cellular homeostasis. As people age, the ECM undergoes changes that can lead to age-related morbidity and mortality. Despite its importance, ECM aging remains understudied in the field of geroscience. In this review, we discuss the core concepts of ECM integrity, outline the age-related challenges and subsequent pathologies and diseases, summarize diagnostic methods detecting a faulty ECM, and provide strategies targeting ECM homeostasis. To conceptualize this, we built a technology research tree to hierarchically visualize possible research sequences for studying ECM aging. This strategic framework will hopefully facilitate the development of future research on interventions to restore ECM integrity, which could potentially lead to the development of new drugs or therapeutic interventions promoting health during aging.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Matriz Extracelular / Longevidad Límite: Humans Idioma: En Revista: Am J Physiol Cell Physiol Asunto de la revista: FISIOLOGIA Año: 2023 Tipo del documento: Article País de afiliación: Suiza Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Matriz Extracelular / Longevidad Límite: Humans Idioma: En Revista: Am J Physiol Cell Physiol Asunto de la revista: FISIOLOGIA Año: 2023 Tipo del documento: Article País de afiliación: Suiza Pais de publicación: Estados Unidos