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Multiple lineages of nematode-Wolbachia symbiosis in supergroup F and convergent loss of bacterioferritin in filarial Wolbachia.
Sinha, Amit; Li, Zhiru; Poole, Catherine B; Ettwiller, Laurence; Lima, Nathália F; Ferreira, Marcelo U; Fombad, Fanny F; Wanji, Samuel; Carlow, Clotilde K S.
Afiliación
  • Sinha A; New England Biolabs, Ipswich, Massachusetts, 01938, USA.
  • Li Z; New England Biolabs, Ipswich, Massachusetts, 01938, USA.
  • Poole CB; New England Biolabs, Ipswich, Massachusetts, 01938, USA.
  • Ettwiller L; New England Biolabs, Ipswich, Massachusetts, 01938, USA.
  • Lima NF; Department of Parasitology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil.
  • Ferreira MU; Department of Parasitology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil.
  • Fombad FF; Department of Microbiology and Parasitology, University of Buea, Buea, Cameroon.
  • Wanji S; Department of Microbiology and Parasitology, University of Buea, Buea, Cameroon.
  • Carlow CKS; New England Biolabs, Ipswich, Massachusetts, 01938, USA.
Genome Biol Evol ; 2023 May 08.
Article en En | MEDLINE | ID: mdl-37154102
The intracellular endosymbiotic proteobacteria Wolbachia have evolved across the phyla nematoda and arthropoda. In Wolbachia phylogeny, supergroup F is the only clade known so far with members from both arthropod and filarial nematode hosts and therefore can provide unique insights into their evolution and biology. In this study, 4 new supergroup F Wolbachia genomes have been assembled using a metagenomic assembly and binning approach, wMoz and wMpe from the human filarial parasites Mansonella ozzardi and Mansonella perstans, and wOcae and wMoviF from the blue mason bee Osmia caerulescens and the sheep ked Melophagus ovinus respectively. A comprehensive phylogenomic analysis revealed two distinct lineages of filarial Wolbachia in supergroup F, indicating multiple horizontal transfer events between arthropod and nematode hosts. The analysis also reveals that the evolution of Wolbachia-filaria symbioses is accompanied by a convergent pseudogenization and loss of the bacterioferritin gene, a phenomenon found to be shared by all filarial Wolbachia, even those outside supergroup F. These observations indicate that differences in heme metabolism might be a key feature distinguishing filarial and arthropod Wolbachia. The new genomes provide a valuable resource for further studies on symbiosis, evolution, and the discovery of new antibiotics to treat mansonellosis.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Genome Biol Evol Asunto de la revista: BIOLOGIA / BIOLOGIA MOLECULAR Año: 2023 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Genome Biol Evol Asunto de la revista: BIOLOGIA / BIOLOGIA MOLECULAR Año: 2023 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Reino Unido