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Tenofovir versus entecavir on the prognosis of hepatitis B virus-related hepatocellular carcinoma: a systematic review and meta-analysis.
Liu, Hui; Han, Cheng-Long; Tian, Bao-Wen; Ding, Zi-Niu; Yang, Ya-Fei; Ma, Yun-Long; Yang, Chun-Cheng; Meng, Guang-Xiao; Xue, Jun-Shuai; Wang, Dong-Xu; Dong, Zhao-Ru; Chen, Zhi-Qiang; Hong, Jian-Guo; Li, Tao.
Afiliación
  • Liu H; Department of General Surgery, Qilu Hospital of Shandong University, Jinan, China.
  • Han CL; Department of General Surgery, Qilu Hospital of Shandong University, Jinan, China.
  • Tian BW; Department of General Surgery, Qilu Hospital of Shandong University, Jinan, China.
  • Ding ZN; Department of General Surgery, Qilu Hospital of Shandong University, Jinan, China.
  • Yang YF; Department of General Surgery, Qilu Hospital of Shandong University, Jinan, China.
  • Ma YL; Department of General Surgery, Qilu Hospital of Shandong University, Jinan, China.
  • Yang CC; Department of General Surgery, Qilu Hospital of Shandong University, Jinan, China.
  • Meng GX; Department of General Surgery, Qilu Hospital of Shandong University, Jinan, China.
  • Xue JS; Department of General Surgery, Qilu Hospital of Shandong University, Jinan, China.
  • Wang DX; Department of General Surgery, Qilu Hospital of Shandong University, Jinan, China.
  • Dong ZR; Department of General Surgery, Qilu Hospital of Shandong University, Jinan, China.
  • Chen ZQ; Department of General Surgery, Qilu Hospital of Shandong University, Jinan, China.
  • Hong JG; Department of General Surgery, Qilu Hospital of Shandong University, Jinan, China.
  • Li T; Department of General Surgery, Qilu Hospital of Shandong University, Jinan, China.
Expert Rev Gastroenterol Hepatol ; 17(6): 623-633, 2023.
Article en En | MEDLINE | ID: mdl-37148261
BACKGROUND: Tenofovir (TDF) and entecavir (ETV) are first-line treatments for patients with chronic hepatitis B virus (HBV) infection. However, the effect of TDF versus ETV on the prognosis of HBV-related hepatocellular carcinoma (HCC) has not been fully clarified yet. RESEARCH DESIGN AND METHODS: PubMed, Embase and Web of science were searched up to March, 2021. Meta-analyses were performed for overall survival (OS), disease-free survival (DFS) and recurrence-free survival (RFS) to assess the effect of TDF versus ETV on the prognosis of HBV-related HCC. RESULTS: A total of 10 studies comprising 4706 Asian patients were included. The pooled results revealed that TDF was associated with better OS (adjusted HR = 0.50, 95% CI: 0.40-0.62; I2 = 36.0%, p = 0.167) and better RFS/DFS (adjusted HR = 0.70, 95% CI: 0.55-0.89, I2 = 71.9%, p = 0.002) than ETV in treatment of HBV-related HCC. Subgroup analysis revealed that OS benefit from TDF was generally consistent, except for patients who underwent non-surgical treatment for HCC. Subgroup analysis also indicated that TDF reduces the risk of late recurrence (HR = 0.41, 95% CI: 0.18-0.0.93; I2 = 63.0%, p = 0.067) rather than early recurrence (HR = 0.99, 95% CI: 0.64-1.52; I2 = 61.3%, p = 0.076). CONCLUSIONS: Compared with ETV, TDF has the advantage of improving OS and reducing late recurrence of patients with HBV-related HCC patients who underwent resection.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Carcinoma Hepatocelular / Hepatitis B Crónica / Neoplasias Hepáticas Tipo de estudio: Diagnostic_studies / Prognostic_studies / Systematic_reviews Límite: Humans Idioma: En Revista: Expert Rev Gastroenterol Hepatol Asunto de la revista: GASTROENTEROLOGIA Año: 2023 Tipo del documento: Article País de afiliación: China Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Carcinoma Hepatocelular / Hepatitis B Crónica / Neoplasias Hepáticas Tipo de estudio: Diagnostic_studies / Prognostic_studies / Systematic_reviews Límite: Humans Idioma: En Revista: Expert Rev Gastroenterol Hepatol Asunto de la revista: GASTROENTEROLOGIA Año: 2023 Tipo del documento: Article País de afiliación: China Pais de publicación: Reino Unido