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Anti­tumor properties of FoxO1 in YD­9 oral squamous cell carcinoma cells.
Kim, Yu Gyung; Seong, Chaeeun; Cho, Kyoung-Ah; Lee, Sang Min; Kim, Tae-Jun; Kim, Hyeon Ji; Cho, Jin-Hwa; Jung, Won; Jang, Sungil; Shin, Jae-Cheon; Lee, Kyung-Ha; Byun, Jin-Seok; Kim, Do-Yeon.
Afiliación
  • Kim YG; Department of Pharmacology, School of Dentistry, Kyungpook National University, Daegu 41940, Republic of Korea.
  • Seong C; Department of Pharmacology, School of Dentistry, Kyungpook National University, Daegu 41940, Republic of Korea.
  • Cho KA; Department of Oral Medicine, School of Dentistry, Kyungpook National University, Daegu 41940, Republic of Korea.
  • Lee SM; Department of Pharmacology, School of Dentistry, Kyungpook National University, Daegu 41940, Republic of Korea.
  • Kim TJ; Department of Pharmacology, School of Dentistry, Kyungpook National University, Daegu 41940, Republic of Korea.
  • Kim HJ; Department of Pharmacology, School of Dentistry, Kyungpook National University, Daegu 41940, Republic of Korea.
  • Cho JH; Department of Pharmacology, School of Dentistry, Kyungpook National University, Daegu 41940, Republic of Korea.
  • Jung W; Department of Oral Medicine, Institute of Oral Bioscience, School of Dentistry, Jeonbuk National University, Jeonju 54896, Republic of Korea.
  • Jang S; Department of Oral Biochemistry, Institute of Oral Bioscience, School of Dentistry, Jeonbuk National University, Jeonju 54896, Republic of Korea.
  • Shin JC; Advanced Bio­Convergence Center, Pohang Technopark, Pohang 37668, Republic of Korea.
  • Lee KH; Department of Molecular Biology, Pusan National University, Busan 46241, Republic of Korea.
  • Byun JS; Department of Oral Medicine, School of Dentistry, Kyungpook National University, Daegu 41940, Republic of Korea.
  • Kim DY; Department of Pharmacology, School of Dentistry, Kyungpook National University, Daegu 41940, Republic of Korea.
Oncol Rep ; 49(6)2023 06.
Article en En | MEDLINE | ID: mdl-37144504
Oral squamous cell carcinoma (OSCC) is a tumor with a poor prognosis and a high recurrence rate. Despite its high annual incidence worldwide, appropriate therapeutic strategies have not yet been developed. Consequently, the 5­year survival rate for OSCC is low when advanced stages or recurrence is diagnosed. Forkhead transcriptional factor O1 (FoxO1) is a key mediator for maintaining cellular homeostasis. FoxO1 can function as a tumor suppressor as well as an oncogene depending on the cancer type. Therefore, the precise molecular functions of FoxO1 need to be validated, considering intracellular factors and the extracellular environment. To the best of our knowledge, however, the roles of FoxO1 in OSCC have not yet been defined. The present study examined FoxO1 levels under pathological conditions (oral lichen planus and oral cancer) and selected an appropriate OSCC cell line (YD­9). Crispr/Cas9 was used to generate FoxO1­deficient YD­9 cells in which the protein levels of phospho ERK and phospho STAT3 were upregulated, promoting cancer proliferation and migration. In addition, FoxO1 reduction increased the levels of the cell proliferation markers phospho H3 (Ser10) and PCNA. FoxO1 loss significantly reduced cellular ROS levels and apoptosis in YD­9 cells. Collectively, the present study demonstrated that FoxO1 exerted an anti­tumor effect by suppressing proliferation and migration/invasion but promoting oxidative stress­linked cell death in YD­9 OSCC cells.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias de la Boca / Carcinoma de Células Escamosas / Neoplasias de Cabeza y Cuello Tipo de estudio: Prognostic_studies Límite: Humans Idioma: En Revista: Oncol Rep Asunto de la revista: NEOPLASIAS Año: 2023 Tipo del documento: Article Pais de publicación: Grecia
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias de la Boca / Carcinoma de Células Escamosas / Neoplasias de Cabeza y Cuello Tipo de estudio: Prognostic_studies Límite: Humans Idioma: En Revista: Oncol Rep Asunto de la revista: NEOPLASIAS Año: 2023 Tipo del documento: Article Pais de publicación: Grecia