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Reversible transitions between noradrenergic and mesenchymal tumor identities define cell plasticity in neuroblastoma.
Thirant, Cécile; Peltier, Agathe; Durand, Simon; Kramdi, Amira; Louis-Brennetot, Caroline; Pierre-Eugène, Cécile; Gautier, Margot; Costa, Ana; Grelier, Amandine; Zaïdi, Sakina; Gruel, Nadège; Jimenez, Irène; Lapouble, Eve; Pierron, Gaëlle; Sitbon, Déborah; Brisse, Hervé J; Gauthier, Arnaud; Fréneaux, Paul; Grossetête, Sandrine; Baudrin, Laura G; Raynal, Virginie; Baulande, Sylvain; Bellini, Angela; Bhalshankar, Jaydutt; Carcaboso, Angel M; Geoerger, Birgit; Rohrer, Hermann; Surdez, Didier; Boeva, Valentina; Schleiermacher, Gudrun; Delattre, Olivier; Janoueix-Lerosey, Isabelle.
Afiliación
  • Thirant C; Institut Curie, Inserm U830, PSL Research University, Diversity and Plasticity of Childhood Tumors Lab, Paris, France.
  • Peltier A; SIREDO: Care, Innovation and Research for Children, Adolescents and Young Adults with Cancer, Institut Curie, Paris, France.
  • Durand S; Institut Curie, Inserm U830, PSL Research University, Diversity and Plasticity of Childhood Tumors Lab, Paris, France.
  • Kramdi A; SIREDO: Care, Innovation and Research for Children, Adolescents and Young Adults with Cancer, Institut Curie, Paris, France.
  • Louis-Brennetot C; Institut Curie, Inserm U830, PSL Research University, Diversity and Plasticity of Childhood Tumors Lab, Paris, France.
  • Pierre-Eugène C; SIREDO: Care, Innovation and Research for Children, Adolescents and Young Adults with Cancer, Institut Curie, Paris, France.
  • Gautier M; Institut Curie, Inserm U830, PSL Research University, Diversity and Plasticity of Childhood Tumors Lab, Paris, France.
  • Costa A; SIREDO: Care, Innovation and Research for Children, Adolescents and Young Adults with Cancer, Institut Curie, Paris, France.
  • Grelier A; Institut Curie, Inserm U830, PSL Research University, Diversity and Plasticity of Childhood Tumors Lab, Paris, France.
  • Zaïdi S; SIREDO: Care, Innovation and Research for Children, Adolescents and Young Adults with Cancer, Institut Curie, Paris, France.
  • Gruel N; Institut Curie, Inserm U830, PSL Research University, Diversity and Plasticity of Childhood Tumors Lab, Paris, France.
  • Jimenez I; SIREDO: Care, Innovation and Research for Children, Adolescents and Young Adults with Cancer, Institut Curie, Paris, France.
  • Lapouble E; Institut Curie, Inserm U830, PSL Research University, Diversity and Plasticity of Childhood Tumors Lab, Paris, France.
  • Pierron G; SIREDO: Care, Innovation and Research for Children, Adolescents and Young Adults with Cancer, Institut Curie, Paris, France.
  • Sitbon D; Institut Curie, Inserm U830, PSL Research University, Diversity and Plasticity of Childhood Tumors Lab, Paris, France.
  • Brisse HJ; SIREDO: Care, Innovation and Research for Children, Adolescents and Young Adults with Cancer, Institut Curie, Paris, France.
  • Gauthier A; Institut Curie, Inserm U830, PSL Research University, Diversity and Plasticity of Childhood Tumors Lab, Paris, France.
  • Fréneaux P; SIREDO: Care, Innovation and Research for Children, Adolescents and Young Adults with Cancer, Institut Curie, Paris, France.
  • Grossetête S; Institut Curie, Inserm U830, PSL Research University, Diversity and Plasticity of Childhood Tumors Lab, Paris, France.
  • Baudrin LG; SIREDO: Care, Innovation and Research for Children, Adolescents and Young Adults with Cancer, Institut Curie, Paris, France.
  • Raynal V; Institut Curie, Inserm U830, PSL Research University, Diversity and Plasticity of Childhood Tumors Lab, Paris, France.
  • Baulande S; Institut Curie, Department of Translational Research, Paris, France.
  • Bellini A; SIREDO: Care, Innovation and Research for Children, Adolescents and Young Adults with Cancer, Institut Curie, Paris, France.
  • Bhalshankar J; Institut Curie, Department of Translational Research, Paris, France.
  • Carcaboso AM; Institut Curie, Laboratoire Recherche Translationnelle en Oncologie Pédiatrique (RTOP), Laboratoire "Gilles Thomas", Paris, France.
  • Geoerger B; Institut Curie, Unité de Génétique Somatique, Paris, France.
  • Rohrer H; Institut Curie, Unité de Génétique Somatique, Paris, France.
  • Surdez D; Institut Curie, Unité de Génétique Somatique, Paris, France.
  • Boeva V; Institut Curie, Department of Imaging, PSL Research University, Paris, France.
  • Schleiermacher G; Institut Curie, Department of Biopathology, Paris, France.
  • Delattre O; Institut Curie, Department of Biopathology, Paris, France.
  • Janoueix-Lerosey I; Institut Curie, Inserm U830, PSL Research University, Diversity and Plasticity of Childhood Tumors Lab, Paris, France.
Nat Commun ; 14(1): 2575, 2023 05 04.
Article en En | MEDLINE | ID: mdl-37142597
Noradrenergic and mesenchymal identities have been characterized in neuroblastoma cell lines according to their epigenetic landscapes and core regulatory circuitries. However, their relationship and relative contribution in patient tumors remain poorly defined. We now document spontaneous and reversible plasticity between the two identities, associated with epigenetic reprogramming, in several neuroblastoma models. Interestingly, xenografts with cells from each identity eventually harbor a noradrenergic phenotype suggesting that the microenvironment provides a powerful pressure towards this phenotype. Accordingly, such a noradrenergic cell identity is systematically observed in single-cell RNA-seq of 18 tumor biopsies and 15 PDX models. Yet, a subpopulation of these noradrenergic tumor cells presents with mesenchymal features that are shared with plasticity models, indicating that the plasticity described in these models has relevance in neuroblastoma patients. This work therefore emphasizes that intrinsic plasticity properties of neuroblastoma cells are dependent upon external cues of the environment to drive cell identity.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Plasticidad de la Célula / Neuroblastoma Límite: Humans Idioma: En Revista: Nat Commun Asunto de la revista: BIOLOGIA / CIENCIA Año: 2023 Tipo del documento: Article País de afiliación: Francia Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Plasticidad de la Célula / Neuroblastoma Límite: Humans Idioma: En Revista: Nat Commun Asunto de la revista: BIOLOGIA / CIENCIA Año: 2023 Tipo del documento: Article País de afiliación: Francia Pais de publicación: Reino Unido