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Dynamic changes of the Prf/Pto tomato resistance complex following effector recognition.
Sheikh, Arsheed H; Zacharia, Iosif; Pardal, Alonso J; Dominguez-Ferreras, Ana; Sueldo, Daniela J; Kim, Jung-Gun; Balmuth, Alexi; Gutierrez, Jose R; Conlan, Brendon F; Ullah, Najeeb; Nippe, Olivia M; Girija, Anil M; Wu, Chih-Hang; Sessa, Guido; Jones, Alexandra M E; Grant, Murray R; Gifford, Miriam L; Mudgett, Mary Beth; Rathjen, John P; Ntoukakis, Vardis.
Afiliación
  • Sheikh AH; School of Life Sciences, University of Warwick, Coventry, CV4 7AL, UK.
  • Zacharia I; Center for Desert Agriculture, BESE Division, King Abdullah University of Science and Technology, Thuwal, 23955-6900, Saudi Arabia.
  • Pardal AJ; School of Life Sciences, University of Warwick, Coventry, CV4 7AL, UK.
  • Dominguez-Ferreras A; School of Life Sciences, University of Warwick, Coventry, CV4 7AL, UK.
  • Sueldo DJ; School of Life Sciences, University of Warwick, Coventry, CV4 7AL, UK.
  • Kim JG; School of Life Sciences, University of Warwick, Coventry, CV4 7AL, UK.
  • Balmuth A; Department of Biology, Faculty of Natural Sciences, Norwegian University of Science and Technology, Hogskoleringen 1, 7491, Trondheim, Norway.
  • Gutierrez JR; Department of Biology, Stanford University, Stanford, CA, 94305, USA.
  • Conlan BF; J.R. Simplot Company, Boise, ID, USA.
  • Ullah N; The Sainsbury Laboratory, Norwich Research Park, Norwich, NR4 7UH, UK.
  • Nippe OM; The Sainsbury Laboratory, Norwich Research Park, Norwich, NR4 7UH, UK.
  • Girija AM; Research School of Biology, The Australian National University, Acton, 2601, ACT, Australia.
  • Wu CH; School of Life Sciences, University of Warwick, Coventry, CV4 7AL, UK.
  • Sessa G; School of Life Sciences, University of Warwick, Coventry, CV4 7AL, UK.
  • Jones AME; School of Plant Sciences and Food Security, Tel-Aviv University, 69978, Tel-Aviv, Israel.
  • Grant MR; The Sainsbury Laboratory, Norwich Research Park, Norwich, NR4 7UH, UK.
  • Gifford ML; School of Plant Sciences and Food Security, Tel-Aviv University, 69978, Tel-Aviv, Israel.
  • Mudgett MB; School of Life Sciences, University of Warwick, Coventry, CV4 7AL, UK.
  • Rathjen JP; School of Life Sciences, University of Warwick, Coventry, CV4 7AL, UK.
  • Ntoukakis V; School of Life Sciences, University of Warwick, Coventry, CV4 7AL, UK.
Nat Commun ; 14(1): 2568, 2023 05 04.
Article en En | MEDLINE | ID: mdl-37142566
In both plants and animals, nucleotide-binding leucine-rich repeat (NLR) immune receptors play critical roles in pathogen recognition and activation of innate immunity. In plants, NLRs recognise pathogen-derived effector proteins and initiate effector-triggered immunity (ETI). However, the molecular mechanisms that link NLR-mediated effector recognition and downstream signalling are not fully understood. By exploiting the well-characterised tomato Prf/Pto NLR resistance complex, we identified the 14-3-3 proteins TFT1 and TFT3 as interacting partners of both the NLR complex and the protein kinase MAPKKKα. Moreover, we identified the helper NRC proteins (NLR-required for cell death) as integral components of the Prf /Pto NLR recognition complex. Notably our studies revealed that TFTs and NRCs interact with distinct modules of the NLR complex and, following effector recognition, dissociate facilitating downstream signalling. Thus, our data provide a mechanistic link between activation of immune receptors and initiation of downstream signalling cascades.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Solanum lycopersicum Límite: Animals Idioma: En Revista: Nat Commun Asunto de la revista: BIOLOGIA / CIENCIA Año: 2023 Tipo del documento: Article Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Solanum lycopersicum Límite: Animals Idioma: En Revista: Nat Commun Asunto de la revista: BIOLOGIA / CIENCIA Año: 2023 Tipo del documento: Article Pais de publicación: Reino Unido