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Current Understanding of the Anatomy, Physiology, and Magnetic Resonance Imaging of Neurofluids: Update From the 2022 "ISMRM Imaging Neurofluids Study group" Workshop in Rome.
Agarwal, Nivedita; Lewis, Laura D; Hirschler, Lydiane; Rivera, Leonardo Rivera; Naganawa, Shinji; Levendovszky, Swati Rane; Ringstad, Geir; Klarica, Marijan; Wardlaw, Joanna; Iadecola, Costantino; Hawkes, Cheryl; Carare, Roxana Octavia; Wells, Jack; Bakker, Erik N T P; Kurtcuoglu, Vartan; Bilston, Lynne; Nedergaard, Maiken; Mori, Yuki; Stoodley, Marcus; Alperin, Noam; de Leon, Mony; van Osch, Matthias J P.
Afiliación
  • Agarwal N; Neuroradiology Unit, Scientific Institute IRCCS E. Medea, Bosisio Parini, Italy.
  • Lewis LD; Department of Biomedical Engineering, Boston University, Boston, Massachusetts, USA.
  • Hirschler L; Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Boston, Massachusetts, USA.
  • Rivera LR; Department of Electrical Engineering and Computer Science, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA.
  • Naganawa S; C.J. Gorter MRI Center, Department of Radiology, Leiden University Medical Center, Leiden, The Netherlands.
  • Levendovszky SR; Wisconsin Alzheimer's Disease Research Center, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, USA.
  • Ringstad G; Department of Radiology, Nagoya University Graduate School of Medicine, Nagoya, Japan.
  • Klarica M; Brain Imaging Core, University of Washington, Seattle, Washington D.C., USA.
  • Wardlaw J; Department of Radiology, Oslo University Hospital Rikshospitalet, Oslo, Norway.
  • Iadecola C; Department of Geriatrics and Internal Medicine, Sorlandet Hospital, Arendal, Norway.
  • Hawkes C; Department of Pharmacology and Croatian Institute of Brain Research, University of Zagreb School of Medicine, Zagreb, Croatia.
  • Carare RO; Centre for Clinical Brain Sciences and UK Dementia Research Institute Centre, University of Edinburgh, Edinburgh, UK.
  • Wells J; Department of Pharmacology and Croatian Institute of Brain Research, University of Zagreb School of Medicine, Zagreb, Croatia.
  • Bakker ENTP; Biomedical and Life Sciences, Lancaster University, Lancaster, UK.
  • Kurtcuoglu V; University of Southampton, Southampton, UK.
  • Bilston L; UCL Centre for Advanced Biomedical Imaging, University College of London, London, UK.
  • Nedergaard M; Biomedical Engineering and Physics, Amsterdam UMC, University of Amsterdam, Amsterdam Cardiovascular Sciences, Amsterdam, The Netherlands.
  • Mori Y; Institute of Physiology, University of Zurich, Zurich, Switzerland.
  • Stoodley M; Neuroscience Research Australia and UNSW Medicine, Sydney, Australia.
  • Alperin N; Center for Translational Neuromedicine, University of Rochester Medical Center, Rochester, New York, USA.
  • de Leon M; Center for Translational Neuromedicine, University of Copenhagen, Copenhagen, Denmark.
  • van Osch MJP; Center for Translational Neuromedicine, University of Copenhagen, Copenhagen, Denmark.
J Magn Reson Imaging ; 59(2): 431-449, 2024 Feb.
Article en En | MEDLINE | ID: mdl-37141288
Neurofluids is a term introduced to define all fluids in the brain and spine such as blood, cerebrospinal fluid, and interstitial fluid. Neuroscientists in the past millennium have steadily identified the several different fluid environments in the brain and spine that interact in a synchronized harmonious manner to assure a healthy microenvironment required for optimal neuroglial function. Neuroanatomists and biochemists have provided an incredible wealth of evidence revealing the anatomy of perivascular spaces, meninges and glia and their role in drainage of neuronal waste products. Human studies have been limited due to the restricted availability of noninvasive imaging modalities that can provide a high spatiotemporal depiction of the brain neurofluids. Therefore, animal studies have been key in advancing our knowledge of the temporal and spatial dynamics of fluids, for example, by injecting tracers with different molecular weights. Such studies have sparked interest to identify possible disruptions to neurofluids dynamics in human diseases such as small vessel disease, cerebral amyloid angiopathy, and dementia. However, key differences between rodent and human physiology should be considered when extrapolating these findings to understand the human brain. An increasing armamentarium of noninvasive MRI techniques is being built to identify markers of altered drainage pathways. During the three-day workshop organized by the International Society of Magnetic Resonance in Medicine that was held in Rome in September 2022, several of these concepts were discussed by a distinguished international faculty to lay the basis of what is known and where we still lack evidence. We envision that in the next decade, MRI will allow imaging of the physiology of neurofluid dynamics and drainage pathways in the human brain to identify true pathological processes underlying disease and to discover new avenues for early diagnoses and treatments including drug delivery. Evidence level: 1 Technical Efficacy: Stage 3.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Encéfalo / Imagen por Resonancia Magnética Tipo de estudio: Prognostic_studies Límite: Animals / Humans País/Región como asunto: Europa Idioma: En Revista: J Magn Reson Imaging Asunto de la revista: DIAGNOSTICO POR IMAGEM Año: 2024 Tipo del documento: Article País de afiliación: Italia Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Encéfalo / Imagen por Resonancia Magnética Tipo de estudio: Prognostic_studies Límite: Animals / Humans País/Región como asunto: Europa Idioma: En Revista: J Magn Reson Imaging Asunto de la revista: DIAGNOSTICO POR IMAGEM Año: 2024 Tipo del documento: Article País de afiliación: Italia Pais de publicación: Estados Unidos