Your browser doesn't support javascript.
loading
Bacteriophage therapy for Escherichia coli-induced urinary tract infection in rats.
Bhargava, Kanika; Nath, Gopal; Dhameja, Neeraj; Kumar, Rajesh; Aseri, Gajender K; Jain, Neelam.
Afiliación
  • Bhargava K; Amity Institute of Microbial Technology, Amity University Rajasthan, Jaipur, Rajasthan, India.
  • Nath G; Department of Microbiology, Institute of Medical Sciences, Banaras Hindu University, Varanasi, Uttar Pradesh, 221005, India.
  • Dhameja N; Department of Microbiology, Institute of Medical Sciences, Banaras Hindu University, Varanasi, Uttar Pradesh, 221005, India.
  • Kumar R; Department of Pathology, Institute of Medical Sciences, Banaras Hindu University, Varanasi, Uttar Pradesh, India.
  • Aseri GK; Department of Microbiology, Institute of Medical Sciences, Banaras Hindu University, Varanasi, Uttar Pradesh, 221005, India.
  • Jain N; Amity Institute of Microbial Technology, Amity University Rajasthan, Jaipur, Rajasthan, India.
Future Microbiol ; 18: 323-334, 2023 04.
Article en En | MEDLINE | ID: mdl-37140267
Antimicrobial resistance is primarily caused by antibiotic overuse and misuse, which results in a decline in the ability of antibiotics to treat infections. Urinary tract infections (UTIs) are common but difficult to treat, as they are frequently caused by multidrug-resistant bacteria. Escherichia coli is a common cause of UTIs. Bacteriophages are a potentially viable alternative for the treatment of bacterial infections, and despite the numerous benefits of using phages as antibacterial therapeutics, there are surprisingly few original research articles based on clinical trials, specifically against UTIs. In this study, the efficiency of a customized bacteriophage cocktail for the treatment of UTIs, with varied doses administered directly into the urinary bladder of rats, was evaluated. At higher concentrations, UTIs were completely eradicated after two doses of the bacteriophage cocktail. However, at lower concentrations, additional doses were required to eradicate the infection. Phage therapy appears to have therapeutic potential, and this study indicates the potential frequency of dosages at appropriate concentrations. Phage therapy was both effective and safe.
Asunto(s)
Palabras clave
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Bacteriófagos / Infecciones Urinarias / Infecciones por Escherichia coli / Escherichia coli Uropatógena / Terapia de Fagos Límite: Animals Idioma: En Revista: Future Microbiol Asunto de la revista: MICROBIOLOGIA Año: 2023 Tipo del documento: Article País de afiliación: India Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Bacteriófagos / Infecciones Urinarias / Infecciones por Escherichia coli / Escherichia coli Uropatógena / Terapia de Fagos Límite: Animals Idioma: En Revista: Future Microbiol Asunto de la revista: MICROBIOLOGIA Año: 2023 Tipo del documento: Article País de afiliación: India Pais de publicación: Reino Unido