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Polymorphisms in the MBL2 gene are associated with the plasma levels of MBL and the cytokines IL-6 and TNF-α in severe COVID-19.
Queiroz, Maria Alice Freitas; Santiago, Angélica Menezes; Brito, Wandrey Roberto Dos Santos; Pereira, Keise Adrielle Santos; de Brito, William Botelho; Torres, Maria Karoliny da Silva; Lopes, Jeferson da Costa; Dos Santos, Erika Ferreira; da Costa, Flávia Póvoa; de Sarges, Kevin Matheus Lima; Cantanhede, Marcos Henrique Damasceno; de Brito, Mioni Thieli Figueiredo Magalhães; da Silva, Andréa Luciana Soares; Leite, Mauro de Meira; Viana, Maria de Nazaré do Socorro de Almeida; Rodrigues, Fabíola Brasil Barbosa; da Silva, Rosilene; Viana, Giselle Maria Rachid; Chaves, Tânia do Socorro Souza; Veríssimo, Adriana de Oliveira Lameira; Carvalho, Mayara da Silva; Henriques, Daniele Freitas; Dos Santos, Carla Pinheiro; Nunes, Juliana Abreu Lima; Costa, Iran Barros; Amoras, Ednelza da Silva Graça; Lima, Sandra Souza; Cayres-Vallinoto, Izaura Maria Vieira; Brasil-Costa, Igor; Quaresma, Juarez Antônio Simões; Falcão, Luiz Fábio Magno; Dos Santos, Eduardo José Melo; Vallinoto, Antonio Carlos Rosário.
Afiliación
  • Queiroz MAF; Laboratory of Virology, Institute of Biological Sciences, Federal University of Pará (UFPA), Belém, Brazil.
  • Santiago AM; Graduate Program in Biology of Infectious and Parasitic Agents, Institute of Biological Sciences, Federal University of Pará (UFPA), Belém, Brazil.
  • Brito WRDS; Laboratory of Virology, Institute of Biological Sciences, Federal University of Pará (UFPA), Belém, Brazil.
  • Pereira KAS; Graduate Program in Virology, Evandro Chagas Institute, Department of Science, Technology, Innovation and Strategic Health Inputs, Ministry of Health of Brazil, Ananindeua, Brazil.
  • de Brito WB; Laboratory of Virology, Institute of Biological Sciences, Federal University of Pará (UFPA), Belém, Brazil.
  • Torres MKDS; Graduate Program in Biology of Infectious and Parasitic Agents, Institute of Biological Sciences, Federal University of Pará (UFPA), Belém, Brazil.
  • Lopes JDC; Laboratory of Virology, Institute of Biological Sciences, Federal University of Pará (UFPA), Belém, Brazil.
  • Dos Santos EF; Graduate Program in Biology of Infectious and Parasitic Agents, Institute of Biological Sciences, Federal University of Pará (UFPA), Belém, Brazil.
  • da Costa FP; Laboratory of Virology, Institute of Biological Sciences, Federal University of Pará (UFPA), Belém, Brazil.
  • de Sarges KML; Graduate Program in Virology, Evandro Chagas Institute, Department of Science, Technology, Innovation and Strategic Health Inputs, Ministry of Health of Brazil, Ananindeua, Brazil.
  • Cantanhede MHD; Laboratory of Virology, Institute of Biological Sciences, Federal University of Pará (UFPA), Belém, Brazil.
  • de Brito MTFM; Graduate Program in Biology of Infectious and Parasitic Agents, Institute of Biological Sciences, Federal University of Pará (UFPA), Belém, Brazil.
  • da Silva ALS; Laboratory of Virology, Institute of Biological Sciences, Federal University of Pará (UFPA), Belém, Brazil.
  • Leite MM; Graduate Program in Biology of Infectious and Parasitic Agents, Institute of Biological Sciences, Federal University of Pará (UFPA), Belém, Brazil.
  • Viana MNDSA; Graduate Program in Biology of Infectious and Parasitic Agents, Institute of Biological Sciences, Federal University of Pará (UFPA), Belém, Brazil.
  • Rodrigues FBB; Laboratory of Genetics of Complex Diseases, Institute of Biological Sciences, Federal University of Pará, Belém, Brazil.
  • da Silva R; Graduate Program in Biology of Infectious and Parasitic Agents, Institute of Biological Sciences, Federal University of Pará (UFPA), Belém, Brazil.
  • Viana GMR; Laboratory of Genetics of Complex Diseases, Institute of Biological Sciences, Federal University of Pará, Belém, Brazil.
  • Chaves TDSS; Graduate Program in Biology of Infectious and Parasitic Agents, Institute of Biological Sciences, Federal University of Pará (UFPA), Belém, Brazil.
  • Veríssimo AOL; Laboratory of Genetics of Complex Diseases, Institute of Biological Sciences, Federal University of Pará, Belém, Brazil.
  • Carvalho MDS; Graduate Program in Biology of Infectious and Parasitic Agents, Institute of Biological Sciences, Federal University of Pará (UFPA), Belém, Brazil.
  • Henriques DF; Laboratory of Genetics of Complex Diseases, Institute of Biological Sciences, Federal University of Pará, Belém, Brazil.
  • Dos Santos CP; Laboratory of Genetics of Complex Diseases, Institute of Biological Sciences, Federal University of Pará, Belém, Brazil.
  • Nunes JAL; Laboratory of Genetics of Complex Diseases, Institute of Biological Sciences, Federal University of Pará, Belém, Brazil.
  • Costa IB; Laboratory of Genetics of Complex Diseases, Institute of Biological Sciences, Federal University of Pará, Belém, Brazil.
  • Amoras EDSG; Graduate Program in Biology of Infectious and Parasitic Agents, Institute of Biological Sciences, Federal University of Pará (UFPA), Belém, Brazil.
  • Lima SS; Laboratory of Genetics of Complex Diseases, Institute of Biological Sciences, Federal University of Pará, Belém, Brazil.
  • Cayres-Vallinoto IMV; Graduate Program in Biology of Infectious and Parasitic Agents, Institute of Biological Sciences, Federal University of Pará (UFPA), Belém, Brazil.
  • Brasil-Costa I; Laboratory of Genetics of Complex Diseases, Institute of Biological Sciences, Federal University of Pará, Belém, Brazil.
  • Quaresma JAS; Graduate Program in Biology of Infectious and Parasitic Agents, Institute of Biological Sciences, Federal University of Pará (UFPA), Belém, Brazil.
  • Falcão LFM; Laboratory of Genetics of Complex Diseases, Institute of Biological Sciences, Federal University of Pará, Belém, Brazil.
  • Dos Santos EJM; Laboratory of Basic Research in Malaria, Parasitology Section, Evandro Chagas Institute, Health and Environment Surveillance Secretariat, Brazilian Ministry of Health, Ananindeua, Brazil.
  • Vallinoto ACR; Laboratory of Basic Research in Malaria, Parasitology Section, Evandro Chagas Institute, Health and Environment Surveillance Secretariat, Brazilian Ministry of Health, Ananindeua, Brazil.
Front Immunol ; 14: 1151058, 2023.
Article en En | MEDLINE | ID: mdl-37138871
Introduction: Mannose-binding lectin (MBL) promotes opsonization, favoring phagocytosis and activation of the complement system in response to different microorganisms, and may influence the synthesis of inflammatory cytokines. This study investigated the association of MBL2 gene polymorphisms with the plasma levels of MBL and inflammatory cytokines in COVID-19. Methods: Blood samples from 385 individuals (208 with acute COVID-19 and 117 post-COVID-19) were subjected to real-time PCR genotyping. Plasma measurements of MBL and cytokines were performed by enzyme-linked immunosorbent assay and flow cytometry, respectively. Results: The frequencies of the polymorphic MBL2 genotype (OO) and allele (O) were higher in patients with severe COVID-19 (p< 0.05). The polymorphic genotypes (AO and OO) were associated with lower MBL levels (p< 0.05). IL-6 and TNF-α were higher in patients with low MBL and severe COVID-19 (p< 0.05). No association of polymorphisms, MBL levels, or cytokine levels with long COVID was observed. Discussion: The results suggest that, besides MBL2 polymorphisms promoting a reduction in MBL levels and therefore in its function, they may also contribute to the development of a more intense inflammatory process responsible for the severity of COVID-19.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Lectina de Unión a Manosa / COVID-19 Tipo de estudio: Risk_factors_studies Límite: Humans Idioma: En Revista: Front Immunol Año: 2023 Tipo del documento: Article País de afiliación: Brasil Pais de publicación: Suiza
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Lectina de Unión a Manosa / COVID-19 Tipo de estudio: Risk_factors_studies Límite: Humans Idioma: En Revista: Front Immunol Año: 2023 Tipo del documento: Article País de afiliación: Brasil Pais de publicación: Suiza