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Clinical Outcomes of Observed and Treated Acute Posterior Multifocal Placoid Pigment Epitheliopathy and Relentless Placoid Chorioretinitis.
Steptoe, Paul J; Pearce, Ian; Beare, Nicholas A V; Sreekantham, Sreekanth; Mohammed, Bashar R; Barry, Robert J; Denniston, Alastair K; Murray, Philip I.
Afiliación
  • Steptoe PJ; Deanery of Clinical Sciences, College of Medicine & Veterinary Medicine, University of Edinburgh, Edinburgh, UK.
  • Pearce I; Princess Alexandra Eye Pavilion, Edinburgh, UK.
  • Beare NAV; St. Paul's Eye Unit, Liverpool University Hospitals NHS Foundation Trust, Liverpool, UK.
  • Sreekantham S; St. Paul's Eye Unit, Liverpool University Hospitals NHS Foundation Trust, Liverpool, UK.
  • Mohammed BR; Department of Eye and Vision Science, Institute of Life Course and Medical Sciences, University of Liverpool, Liverpool, UK.
  • Barry RJ; Birmingham and Midland Eye Centre, Birmingham, UK.
  • Denniston AK; Birmingham and Midland Eye Centre, Birmingham, UK.
  • Murray PI; Birmingham and Midland Eye Centre, Birmingham, UK.
Ocul Immunol Inflamm ; : 1-7, 2023 May 03.
Article en En | MEDLINE | ID: mdl-37134304
PURPOSE: To assess the efficacy of treatment on acute posterior multifocal placoid pigment epitheliopathy (APMPPE) and relentless placoid chorioretinopathy (RPC). METHODS: Cases were identified from three UK uveitis centers. Retrospective analysis of visual acuity recovery; OCT structural outcomes; and retinal lesion quantification in observed and treated cases of APMPPE/RPC. RESULTS: There were nine APMPPE and three RPC cases. Out of 12 patients, six were female. Median age: 26.5 years (range, 20-57 years). Four cases (six eyes) were observed, and eight cases (15 eyes) received corticosteroids ± immunosuppression. 4/4 observed and 6/10 treated foveal involving eyes regained 0.00 LogMAR vision. Observed lesions achieved more favorable anatomical outcomes. New lesions post-presentation developed in 1/6 (16%) observed eye versus 10/15 (66%) treated eyes. In three cases, a delayed, rebound lesion occurrence was observed post-high-dose corticosteroids. CONCLUSIONS: While subject to potential treatment bias, in this small case series, natural history alone appears non-inferior to corticosteroid treatment.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Prognostic_studies Idioma: En Revista: Ocul Immunol Inflamm Asunto de la revista: ALERGIA E IMUNOLOGIA / OFTALMOLOGIA Año: 2023 Tipo del documento: Article Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Prognostic_studies Idioma: En Revista: Ocul Immunol Inflamm Asunto de la revista: ALERGIA E IMUNOLOGIA / OFTALMOLOGIA Año: 2023 Tipo del documento: Article Pais de publicación: Reino Unido