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Protein intake and risk of urolithiasis and kidney diseases: an umbrella review of systematic reviews for the evidence-based guideline of the German Nutrition Society.
Remer, Thomas; Kalotai, Nicole; Amini, Anna M; Lehmann, Andreas; Schmidt, Annemarie; Bischoff-Ferrari, Heike A; Egert, Sarah; Ellinger, Sabine; Kroke, Anja; Kühn, Tilman; Lorkowski, Stefan; Nimptsch, Katharina; Schwingshackl, Lukas; Zittermann, Armin; Watzl, Bernhard; Siener, Roswitha.
Afiliación
  • Remer T; DONALD Study Center Dortmund, Department of Nutritional Epidemiology, Institute of Nutrition and Food Science, University of Bonn, Heinstück 11, 44225, Dortmund, Germany. corresponding_author@dge.de.
  • Kalotai N; German Nutrition Society, Bonn, Germany.
  • Amini AM; German Nutrition Society, Bonn, Germany.
  • Lehmann A; German Nutrition Society, Bonn, Germany.
  • Schmidt A; German Nutrition Society, Bonn, Germany.
  • Bischoff-Ferrari HA; Department of Aging Medicine and Aging Research, University Hospital Zurich, University of Zurich, and City Hospital Zurich, Zurich, Switzerland.
  • Egert S; Department of Nutrition and Food Science, Nutritional Physiology, University of Bonn, Bonn, Germany.
  • Ellinger S; Department of Nutrition and Food Science, Human Nutrition, University of Bonn, Bonn, Germany.
  • Kroke A; Department of Nutritional, Food and Consumer Sciences, Fulda University of Applied Sciences, Fulda, Germany.
  • Kühn T; The Institute for Global Food Security, Queen's University Belfast, Belfast, Northern Ireland, UK.
  • Lorkowski S; Faculty of Medicine and University Hospital, Heidelberg Institute of Global Health (HIGH), Heidelberg, Germany.
  • Nimptsch K; Department of Nutritional Sciences, University of Vienna, Vienna, Austria.
  • Schwingshackl L; Center for Public Health, Medical University of Vienna, Vienna, Austria.
  • Zittermann A; Institute of Nutritional Sciences, Friedrich Schiller, University Jena, Jena, Germany.
  • Watzl B; Competence Cluster for Nutrition and Cardiovascular, Health (nutriCARD) Halle-Jena-Leipzig, Jena, Germany.
  • Siener R; Molecular Epidemiology Research Group, Max Delbrück Center for Molecular Medicine (MDC) in the Helmholtz Association, Berlin, Germany.
Eur J Nutr ; 62(5): 1957-1975, 2023 Aug.
Article en En | MEDLINE | ID: mdl-37133532
PURPOSE: Changes in dietary protein intake metabolically affect kidney functions. However, knowledge on potential adverse consequences of long-term higher protein intake (HPI) for kidney health is lacking. To summarise and evaluate the available evidence for a relation between HPI and kidney diseases, an umbrella review of systematic reviews (SR) was conducted. METHODS: PubMed, Embase and Cochrane Database of SRs published until 12/2022 were searched for the respective SRs with and without meta-analyses (MA) of randomised controlled trials or cohort studies. For assessments of methodological quality and of outcome-specific certainty of evidence, a modified version of AMSTAR 2 and the NutriGrade scoring tool were used, respectively. The overall certainty of evidence was assessed according to predefined criteria. RESULTS: Six SRs with MA and three SRs without MA on various kidney-related outcomes were identified. Outcomes were chronic kidney disease, kidney stones and kidney function-related parameters: albuminuria, glomerular filtration rate, serum urea, urinary pH and urinary calcium excretion. Overall certainty of evidence was graded as 'possible' for stone risk not to be associated with HPI and albuminuria not to be elevated through HPI (above recommendations (> 0.8 g/kg body weight/day)) and graded as 'probable' or 'possible' for most other kidney function-related parameters to be physiologically increased with HPI. CONCLUSION: Changes of the assessed outcomes may have reflected mostly physiological (regulatory), but not pathometabolic responses to higher protein loads. For none of the outcomes, evidence was found that HPI does specifically trigger kidney stones or diseases. However, for potential recommendations long-term data, also over decades, are required.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Cálculos Renales / Albuminuria Tipo de estudio: Clinical_trials / Etiology_studies / Guideline / Observational_studies / Prognostic_studies / Risk_factors_studies / Systematic_reviews Límite: Humans Idioma: En Revista: Eur J Nutr Asunto de la revista: CIENCIAS DA NUTRICAO Año: 2023 Tipo del documento: Article País de afiliación: Alemania Pais de publicación: Alemania

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Cálculos Renales / Albuminuria Tipo de estudio: Clinical_trials / Etiology_studies / Guideline / Observational_studies / Prognostic_studies / Risk_factors_studies / Systematic_reviews Límite: Humans Idioma: En Revista: Eur J Nutr Asunto de la revista: CIENCIAS DA NUTRICAO Año: 2023 Tipo del documento: Article País de afiliación: Alemania Pais de publicación: Alemania