Dihydroartemisinin inhibited stem cell-like properties and enhanced oxaliplatin sensitivity of colorectal cancer via AKT/mTOR signaling.

Wang, Yujun; Yang, Zhirong; Zhu, Wanglong; Chen, Yuzhuo; He, Xingqiang; Li, Jiaofeng; Han, Zhengyu; Yang, Yuhan; Liu, Wei; Zhang, Kun

Wang, Yujun; Yang, Zhirong; Zhu, Wanglong; Chen, Yuzhuo; He, Xingqiang; Li, Jiaofeng; Han, Zhengyu; Yang, Yuhan; Liu, Wei; Zhang, Kun.

Afiliación

Wang Y; School of Pharmacy, Chengdu Medical College, Chengdu, China.
Yang Z; The Second Affiliated Hospital of Chengdu Medical College, China National Nuclear Corporation 416 Hospital, Chengdu, China.
Zhu W; Pathology Department, Deyang People's Hospital, Deyang, China.
Chen Y; The Second Affiliated Hospital of Chengdu Medical College, China National Nuclear Corporation 416 Hospital, Chengdu, China.
He X; School of Biological Sciences and Technology, Chengdu Medical College, Chengdu, China.
Li J; School of Pharmacy, Chengdu Medical College, Chengdu, China.
Han Z; College of Laboratory Medicine, Chengdu Medical College, Chengdu, China.
Yang Y; School of Pharmacy, Chengdu Medical College, Chengdu, China.
Liu W; School of Biological Sciences and Technology, Chengdu Medical College, Chengdu, China.
Zhang K; The Second Affiliated Hospital of Chengdu Medical College, China National Nuclear Corporation 416 Hospital, Chengdu, China.

Drug Dev Res ; 84(5): 988-998, 2023 08.

Article en En | MEDLINE | ID: mdl-37132439

Asunto(s)

Neoplasias Colorrectales; Proteínas Proto-Oncogénicas c-akt; Animales; Ratones; Oxaliplatino/farmacología; Oxaliplatino/uso terapéutico; Proteínas Proto-Oncogénicas c-akt/metabolismo; Neoplasias Colorrectales/tratamiento farmacológico; Neoplasias Colorrectales/metabolismo; Ratones Desnudos; Transducción de Señal; Serina-Treonina Quinasas TOR/metabolismo; Células Madre Neoplásicas; Línea Celular Tumoral; Proliferación Celular

Palabras clave

AKT/mTOR signaling; cancer stem-like cells; colorectal cancer; dihydroartemisinin; resistance

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias Colorrectales / Proteínas Proto-Oncogénicas c-akt Tipo de estudio: Diagnostic_studies Límite: Animals Idioma: En Revista: Drug Dev Res Año: 2023 Tipo del documento: Article País de afiliación: China Pais de publicación: Estados Unidos

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