<i>In silico</i> mutation of aromatic with aliphatic amino acid residues in <i>Clostridium perfringens</i> epsilon toxin (ETX) reduces its binding efficiency to Caprine Myelin and lymphocyte (MAL) protein receptors.

Kumar, Sunil; Behera, Santosh Kumar; Gururaj, Kumaresan; Chaurasia, Anurag; Murmu, Sneha; Prabha, Ratna; Angadi, U B; Pawaiya, Rajveer Singh; Rai, Anil

In silico mutation of aromatic with aliphatic amino acid residues in Clostridium perfringens epsilon toxin (ETX) reduces its binding efficiency to Caprine Myelin and lymphocyte (MAL) protein receptors.

Kumar, Sunil; Behera, Santosh Kumar; Gururaj, Kumaresan; Chaurasia, Anurag; Murmu, Sneha; Prabha, Ratna; Angadi, U B; Pawaiya, Rajveer Singh; Rai, Anil.

Afiliación

Kumar S; ICAR-Indian Agricultural Statistics Research Institute, New Delhi, India.
Behera SK; National Institute of Pharmaceutical Education and Research, Ahmedabad, India.
Gururaj K; ICAR-Central Institute for Research on Goats, Makhdoom, Mathura, India.
Chaurasia A; ICAR-Indian Institute of Vegetable Research, Varanasi, India.
Murmu S; ICAR-Indian Agricultural Statistics Research Institute, New Delhi, India.
Prabha R; ICAR-Indian Agricultural Statistics Research Institute, New Delhi, India.
Angadi UB; ICAR-Indian Agricultural Statistics Research Institute, New Delhi, India.
Pawaiya RS; ICAR-Central Institute for Research on Goats, Makhdoom, Mathura, India.
Rai A; ICAR-Indian Agricultural Statistics Research Institute, New Delhi, India.

J Biomol Struct Dyn ; 42(5): 2257-2269, 2024 Mar.

Article en En | MEDLINE | ID: mdl-37129165

Asunto(s)

Toxinas Bacterianas; Clostridium perfringens; Vaina de Mielina; Animales; Aminoácidos/metabolismo; Clostridium perfringens/genética; Clostridium perfringens/metabolismo; Enterotoxemia; Cabras; Linfocitos; Mutación; Proteínas de la Mielina/genética; Proteínas Proteolipídicas Asociadas a Mielina y Linfocito/metabolismo; Toxinas Bacterianas/genética; Toxinas Bacterianas/metabolismo

Palabras clave

Epsilon toxin (ETX); MAL protein; enterotoxaemia (ET); molecular dynamics; protein-protein interactions

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Toxinas Bacterianas / Clostridium perfringens / Vaina de Mielina Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Revista: J Biomol Struct Dyn Año: 2024 Tipo del documento: Article País de afiliación: India Pais de publicación: Reino Unido

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