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Role of tumor-associated macrophages in common digestive system malignant tumors.
Shen, Yue; Chen, Jia-Xi; Li, Ming; Xiang, Ze; Wu, Jian; Wang, Yi-Jin.
Afiliación
  • Shen Y; Department of Dermatology, Suzhou Municipal Hospital, Suzhou 215008, Jiangsu Province, China.
  • Chen JX; School of Medicine, Zhejiang University, Hangzhou 310009, Zhejiang Province, China.
  • Li M; Department of Pathology, Suzhou Municipal Hospital, Suzhou 215008, Jiangsu Province, China.
  • Xiang Z; School of Medicine, Zhejiang University, Hangzhou 310009, Zhejiang Province, China.
  • Wu J; Department of Clinical Laboratory, Suzhou Municipal Hospital, Suzhou 215008, Jiangsu Province, China.
  • Wang YJ; School of Medicine, Southern University of Science and Technology, Shenzhen 518055, Guangdong Province, China. wangyj3@sustech.edu.cn.
World J Gastrointest Oncol ; 15(4): 596-616, 2023 Apr 15.
Article en En | MEDLINE | ID: mdl-37123058
Many digestive system malignant tumors are characterized by high incidence and mortality rate. Increasing evidence has revealed that the tumor microenvironment (TME) is involved in cancer initiation and tumor progression. Tumor-associated macrophages (TAMs) are a predominant constituent of the TME, and participate in the regulation of various biological behaviors and influence the prognosis of digestive system cancer. TAMs can be mainly classified into the antitumor M1 phenotype and protumor M2 phenotype. The latter especially are crucial drivers of tumor invasion, growth, angiogenesis, metastasis, immunosuppression, and resistance to therapy. TAMs are of importance in the occurrence, development, diagnosis, prognosis, and treatment of common digestive system malignant tumors. In this review, we summarize the role of TAMs in common digestive system malignant tumors, including esophageal, gastric, colorectal, pancreatic and liver cancers. How TAMs promote the development of tumors, and how they act as potential therapeutic targets and their clinical applications are also described.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Risk_factors_studies Idioma: En Revista: World J Gastrointest Oncol Año: 2023 Tipo del documento: Article País de afiliación: China Pais de publicación: China
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Risk_factors_studies Idioma: En Revista: World J Gastrointest Oncol Año: 2023 Tipo del documento: Article País de afiliación: China Pais de publicación: China