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Weight of evidence evaluation for chemical-induced immunotoxicity for PFOA and PFOS: findings from an independent panel of experts.
Garvey, Gregory J; Anderson, Janet K; Goodrum, Philip E; Tyndall, Kirby H; Cox, L Anthony; Khatami, Mahin; Morales-Montor, Jorge; Schoeny, Rita S; Seed, Jennifer G; Tyagi, Rajeev K; Kirman, Christopher R; Hays, Sean M.
Afiliación
  • Garvey GJ; GSI Environmental, Houston, TX, USA.
  • Anderson JK; GSI Environmental, Austin, TX, USA.
  • Goodrum PE; GSI Environmental, Fayetteville, NY, USA.
  • Tyndall KH; Independent Consultant, Austin, TX, USA.
  • Cox LA; Business Analytics, University of Colorado, Denver, CO, USA.
  • Khatami M; NCI/NIH, Bethesda, MD, USA.
  • Morales-Montor J; Department of Immunology, Universidad Nacional Autonoma De Mexico, Mexico City, Mexico.
  • Schoeny RS; Rita Schoeny LLC, Washington, DC, USA.
  • Seed JG; Independent Consultant, Alexandria, VA, USA.
  • Tyagi RK; CSIR-Institute of Microbial Technology (IMTECH), Chandigarh, India.
  • Kirman CR; SciPinion, Bozeman, MT, USA.
  • Hays SM; SciPinion, Bozeman, MT, USA.
Crit Rev Toxicol ; 53(1): 34-51, 2023 01.
Article en En | MEDLINE | ID: mdl-37115714
Immunotoxicity is the critical endpoint used by some regulatory agencies to establish toxicity values for perfluorooctanoic acid (PFOA) and perfluorooctane sulfonate (PFOS). However, the hypothesis that exposure to certain per- and polyfluoroalkyl substances (PFAS) causes immune dysregulation is subject to much debate. An independent, international expert panel was engaged utilizing methods to reduce bias and "groupthink". The panel concluded there is moderate evidence that PFOS and PFOA are immunotoxic, based primarily on evidence from animal data. However, species concordance and human relevance cannot be well established due to data limitations. The panel recommended additional testing that includes longer-term exposures, evaluates both genders, includes other species of animals, tests lower dose levels, assesses more complete measures of immune responses, and elucidates the mechanism of action. Panel members agreed that the Faroe Islands cohort data should not be used as the primary basis for deriving PFAS risk assessment values. The panel agreed that vaccine antibody titer is not useful as a stand-alone metric for risk assessment. Instead, PFOA and PFOS toxicity values should rely on multiple high-quality studies, which are currently not available for immune suppression. The panel concluded that the available PFAS immune epidemiology studies suffer from weaknesses in study design that preclude their use, whereas available animal toxicity studies provide comprehensive dataset to derive points of departure (PODs) for non-immune endpoints. The panel recommends accounting for potential PFAS immunotoxicity by applying a database uncertainty factor to POD values derived from animal studies for other more robustly supported critical effects.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Ácidos Alcanesulfónicos / Fluorocarburos Tipo de estudio: Diagnostic_studies / Observational_studies / Risk_factors_studies Límite: Animals / Female / Humans / Male Idioma: En Revista: Crit Rev Toxicol Asunto de la revista: TOXICOLOGIA Año: 2023 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Ácidos Alcanesulfónicos / Fluorocarburos Tipo de estudio: Diagnostic_studies / Observational_studies / Risk_factors_studies Límite: Animals / Female / Humans / Male Idioma: En Revista: Crit Rev Toxicol Asunto de la revista: TOXICOLOGIA Año: 2023 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Reino Unido