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Exploring semantic verbal fluency patterns and their relationship to age and Alzheimer's disease in adults with Down syndrome.
Mgaieth, Farah; Baksh, R Asaad; Startin, Carla M; Hamburg, Sarah; Hithersay, Rosalyn; Pape, Sarah; Zetterberg, Henrik; Ashton, Nicholas J; Tamayo-Elizalde, Miren; Saini, Fedal; Idris, Mina; Consortium, The LonDownS; Strydom, Andre.
Afiliación
  • Mgaieth F; Department of Forensic and Neurodevelopmental Sciences, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK.
  • Baksh RA; Department of Forensic and Neurodevelopmental Sciences, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK.
  • Startin CM; The LonDownS Consortium, London, UK.
  • Hamburg S; Department of Forensic and Neurodevelopmental Sciences, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK.
  • Hithersay R; The LonDownS Consortium, London, UK.
  • Pape S; Division of Psychiatry, University College London, London, UK.
  • Zetterberg H; School of Psychology, University of Roehampton, London, UK.
  • Ashton NJ; The LonDownS Consortium, London, UK.
  • Tamayo-Elizalde M; Department of Forensic and Neurodevelopmental Sciences, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK.
  • Saini F; The LonDownS Consortium, London, UK.
  • Idris M; Division of Psychiatry, University College London, London, UK.
  • Consortium TL; Department of Forensic and Neurodevelopmental Sciences, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK.
  • Strydom A; South London and Maudsley NHS Foundation Trust, London, UK.
Alzheimers Dement ; 19(11): 5129-5137, 2023 Nov.
Article en En | MEDLINE | ID: mdl-37114906
INTRODUCTION: Adults with Down syndrome (DS) are at ultra-high risk of developing Alzheimer's disease (AD), characterized by poor episodic memory and semantic fluency in the preclinical phase in the general population. We explored semantic fluency performance in DS and its relationship to age, AD, and blood biomarkers. METHODS: A total of 302 adults with DS at baseline and 87 at follow-up from the London Down Syndrome Consortium cohort completed neuropsychological assessments. Blood biomarkers were measured with the single molecule array technique in a subset of 94 participants. RESULTS: Poorer verbal fluency performance was observed as age increases. Number of correct words declined in those with AD compared to those without over 2 years and was negatively correlated with neurofilament light (r = -0.37, P = .001) and glial fibrillary acidic protein (r = -0.31, P = .012). DISCUSSION: Semantic fluency may be useful as an early indicator of cognitive decline and provide additional information on AD-related change, showing associations with biomarkers in DS.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Síndrome de Down / Enfermedad de Alzheimer Límite: Adult / Humans Idioma: En Revista: Alzheimers Dement Año: 2023 Tipo del documento: Article Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Síndrome de Down / Enfermedad de Alzheimer Límite: Adult / Humans Idioma: En Revista: Alzheimers Dement Año: 2023 Tipo del documento: Article Pais de publicación: Estados Unidos