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ß-Tricalcium Phosphate-Modified Aerogel Containing PVA/Chitosan Hybrid Nanospun Scaffolds for Bone Regeneration.
Boda, Róbert; Lázár, István; Keczánné-Üveges, Andrea; Bakó, József; Tóth, Ferenc; Trencsényi, György; Kálmán-Szabó, Ibolya; Béresová, Monika; Sajtos, Zsófi; D Tóth, Etelka; Deák, Ádám; Tóth, Adrienn; Horváth, Dóra; Gaál, Botond; Daróczi, Lajos; Dezso, Balázs; Ducza, László; Hegedus, Csaba.
Afiliación
  • Boda R; Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, University of Debrecen, 4032 Debrecen, Hungary.
  • Lázár I; Department of Inorganic and Analytical Chemistry, Faculty of Science and Technology, University of Debrecen, 4032 Debrecen, Hungary.
  • Keczánné-Üveges A; Department of Biomaterials and Prosthetic Dentistry, Faculty of Dentistry, University of Debrecen, 4032 Debrecen, Hungary.
  • Bakó J; Department of Biomaterials and Prosthetic Dentistry, Faculty of Dentistry, University of Debrecen, 4032 Debrecen, Hungary.
  • Tóth F; Department of Biomaterials and Prosthetic Dentistry, Faculty of Dentistry, University of Debrecen, 4032 Debrecen, Hungary.
  • Trencsényi G; Division of Nuclear Medicine and Translational Imaging, Department of Medical Imaging, Faculty of Medicine, University of Debrecen, 4032 Debrecen, Hungary.
  • Kálmán-Szabó I; Division of Nuclear Medicine and Translational Imaging, Department of Medical Imaging, Faculty of Medicine, University of Debrecen, 4032 Debrecen, Hungary.
  • Béresová M; Department of Medical Imaging, Faculty of Medicine, University of Debrecen, 4032 Debrecen, Hungary.
  • Sajtos Z; Department of Inorganic and Analytical Chemistry, Faculty of Science and Technology, University of Debrecen, 4032 Debrecen, Hungary.
  • D Tóth E; Department of Dentoalveolar Surgery, University of Debrecen, 4032 Debrecen, Hungary.
  • Deák Á; Department of Operative Techniques and Surgical Research, Faculty of Medicine, University of Debrecen, 4032 Debrecen, Hungary.
  • Tóth A; Department of Dentoalveolar Surgery, University of Debrecen, 4032 Debrecen, Hungary.
  • Horváth D; Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, University of Debrecen, 4032 Debrecen, Hungary.
  • Gaál B; Department of Anatomy, Histology and Embryology, Faculty of Medicine, University of Debrecen, 4032 Debrecen, Hungary.
  • Daróczi L; Department of Solid State Physics, University of Debrecen, 4002 Debrecen, Hungary.
  • Dezso B; Department of Oral Pathology and Microbiology, Faculty of Dentistry, University of Debrecen, 4032 Debrecen, Hungary.
  • Ducza L; Department of Anatomy, Histology and Embryology, Faculty of Medicine, University of Debrecen, 4032 Debrecen, Hungary.
  • Hegedus C; Department of Biomaterials and Prosthetic Dentistry, Faculty of Dentistry, University of Debrecen, 4032 Debrecen, Hungary.
Int J Mol Sci ; 24(8)2023 Apr 20.
Article en En | MEDLINE | ID: mdl-37108742
Electrospinning has recently been recognized as a potential method for use in biomedical applications such as nanofiber-based drug delivery or tissue engineering scaffolds. The present study aimed to demonstrate the electrospinning preparation and suitability of ß-tricalcium phosphate-modified aerogel containing polyvinyl alcohol/chitosan fibrous meshes (BTCP-AE-FMs) for bone regeneration under in vitro and in vivo conditions. The mesh physicochemical properties included a 147 ± 50 nm fibrous structure, in aqueous media the contact angles were 64.1 ± 1.7°, and it released Ca, P, and Si. The viability of dental pulp stem cells on the BTCP-AE-FM was proven by an alamarBlue assay and with a scanning electron microscope. Critical-size calvarial defects in rats were performed as in vivo experiments to investigate the influence of meshes on bone regeneration. PET imaging using 18F-sodium fluoride standardized uptake values (SUVs) detected 7.40 ± 1.03 using polyvinyl alcohol/chitosan fibrous meshes (FMs) while 10.72 ± 1.11 with BTCP-AE-FMs after 6 months. New bone formations were confirmed by histological analysis. Despite a slight change in the morphology of the mesh because of cross-linking, the BTCP-AE-FM basically retained its fibrous, porous structure and hydrophilic and biocompatible character. Our experiments proved that hybrid nanospun scaffold composite mesh could be a new experimental bone substitute bioactive material in future medical practice.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Quitosano Límite: Animals Idioma: En Revista: Int J Mol Sci Año: 2023 Tipo del documento: Article País de afiliación: Hungria Pais de publicación: Suiza
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Quitosano Límite: Animals Idioma: En Revista: Int J Mol Sci Año: 2023 Tipo del documento: Article País de afiliación: Hungria Pais de publicación: Suiza