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Leveraging base-pair mammalian constraint to understand genetic variation and human disease.
Sullivan, Patrick F; Meadows, Jennifer R S; Gazal, Steven; Phan, BaDoi N; Li, Xue; Genereux, Diane P; Dong, Michael X; Bianchi, Matteo; Andrews, Gregory; Sakthikumar, Sharadha; Nordin, Jessika; Roy, Ananya; Christmas, Matthew J; Marinescu, Voichita D; Wang, Chao; Wallerman, Ola; Xue, James; Yao, Shuyang; Sun, Quan; Szatkiewicz, Jin; Wen, Jia; Huckins, Laura M; Lawler, Alyssa; Keough, Kathleen C; Zheng, Zhili; Zeng, Jian; Wray, Naomi R; Li, Yun; Johnson, Jessica; Chen, Jiawen; Paten, Benedict; Reilly, Steven K; Hughes, Graham M; Weng, Zhiping; Pollard, Katherine S; Pfenning, Andreas R; Forsberg-Nilsson, Karin; Karlsson, Elinor K; Lindblad-Toh, Kerstin.
Afiliación
  • Sullivan PF; Department of Genetics, University of North Carolina Medical School, Chapel Hill, NC 27599, USA.
  • Meadows JRS; Department of Medical Epidemiology and Biostatistics, Karolinska Institute, 17177 Stockholm, Sweden.
  • Gazal S; Department of Medical Biochemistry and Microbiology, Science for Life Laboratory, Uppsala University, 75132 Uppsala, Sweden.
  • Phan BN; Department of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA.
  • Li X; Center for Genetic Epidemiology, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA.
  • Genereux DP; Department of Computational Biology, School of Computer Science, Carnegie Mellon University, Pittsburgh, PA 15213, USA.
  • Dong MX; Program in Bioinformatics and Integrative Biology, University of Massachusetts Medical School, Worcester, MA 01605, USA.
  • Bianchi M; Broad Institute of MIT and Harvard, Cambridge, MA 02139, USA.
  • Andrews G; Program in Bioinformatics and Integrative Biology, University of Massachusetts Medical School, Worcester, MA 01605, USA.
  • Sakthikumar S; Department of Medical Biochemistry and Microbiology, Science for Life Laboratory, Uppsala University, 75132 Uppsala, Sweden.
  • Nordin J; Department of Medical Biochemistry and Microbiology, Science for Life Laboratory, Uppsala University, 75132 Uppsala, Sweden.
  • Roy A; Program in Bioinformatics and Integrative Biology, University of Massachusetts Medical School, Worcester, MA 01605, USA.
  • Christmas MJ; Department of Medical Biochemistry and Microbiology, Science for Life Laboratory, Uppsala University, 75132 Uppsala, Sweden.
  • Marinescu VD; Broad Institute of MIT and Harvard, Cambridge, MA 02139, USA.
  • Wang C; Department of Medical Biochemistry and Microbiology, Science for Life Laboratory, Uppsala University, 75132 Uppsala, Sweden.
  • Wallerman O; Department of Immunology, Genetics and Pathology, Science for Life Laboratory, Uppsala University, 75185 Uppsala, Sweden.
  • Xue J; Department of Medical Biochemistry and Microbiology, Science for Life Laboratory, Uppsala University, 75132 Uppsala, Sweden.
  • Yao S; Department of Medical Biochemistry and Microbiology, Science for Life Laboratory, Uppsala University, 75132 Uppsala, Sweden.
  • Sun Q; Department of Medical Biochemistry and Microbiology, Science for Life Laboratory, Uppsala University, 75132 Uppsala, Sweden.
  • Szatkiewicz J; Department of Medical Biochemistry and Microbiology, Science for Life Laboratory, Uppsala University, 75132 Uppsala, Sweden.
  • Wen J; Broad Institute of MIT and Harvard, Cambridge, MA 02139, USA.
  • Huckins LM; Center for System Biology, Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, MA 02138, USA.
  • Lawler A; Department of Medical Epidemiology and Biostatistics, Karolinska Institute, 17177 Stockholm, Sweden.
  • Keough KC; Department of Genetics, University of North Carolina Medical School, Chapel Hill, NC 27599, USA.
  • Zheng Z; Department of Genetics, University of North Carolina Medical School, Chapel Hill, NC 27599, USA.
  • Zeng J; Department of Genetics, University of North Carolina Medical School, Chapel Hill, NC 27599, USA.
  • Wray NR; Department of Genetic and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
  • Li Y; Neuroscience Institute, Carnegie Mellon University, Pittsburgh, PA 15213, USA.
  • Johnson J; Department of Biological Sciences, Carnegie Mellon University, Pittsburgh, PA 15213, USA.
  • Chen J; Gladstone Institutes, San Francisco, CA 94158, USA.
  • Paten B; Institute for Molecular Bioscience, University of Queensland, Brisbane, QLD 4072, Australia.
  • Reilly SK; Institute for Molecular Bioscience, University of Queensland, Brisbane, QLD 4072, Australia.
  • Hughes GM; Institute for Molecular Bioscience, University of Queensland, Brisbane, QLD 4072, Australia.
  • Weng Z; Department of Genetics, University of North Carolina Medical School, Chapel Hill, NC 27599, USA.
  • Pollard KS; Department of Genetic and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
  • Pfenning AR; Department of Biostatistics, University of North Carolina Medical School, Chapel Hill, NC 27599, USA.
  • Karlsson EK; UC Santa Cruz Genomics Institute, Santa Cruz, CA 95064, USA.
  • Lindblad-Toh K; Department of Genetics, Yale School of Medicine, New Haven, CT 06510, USA.
Science ; 380(6643): eabn2937, 2023 04 28.
Article en En | MEDLINE | ID: mdl-37104612
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Variación Genética / Enfermedad Tipo de estudio: Prognostic_studies Límite: Animals / Humans Idioma: En Revista: Science Año: 2023 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
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XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Variación Genética / Enfermedad Tipo de estudio: Prognostic_studies Límite: Animals / Humans Idioma: En Revista: Science Año: 2023 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos