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Induction Chemotherapy With 5-Fluorouracil, Cisplatin, and Cetuximab in Advanced Head and Neck Squamous Cell Carcinoma.
Yamauchi, Moriyasu; Minesaki, Akimichi; Ishida, Tomoya; Sato, Yuki; Okamura, Seiji; Shuto, Hiroyuki; Tanaka, Nariyuki; Hatayama, Eriko; Shibamiya, Natsuko; Kuratomi, Yuichiro.
Afiliación
  • Yamauchi M; Department of Otolaryngology - Head & Neck Surgery, Saga University Faculty of Medicine, Saga, Japan yamamori@cc.saga-u.ac.jp.
  • Minesaki A; Department of Otolaryngology - Head & Neck Surgery, Saga University Faculty of Medicine, Saga, Japan.
  • Ishida T; Department of Otolaryngology - Head & Neck Surgery, Saga University Faculty of Medicine, Saga, Japan.
  • Sato Y; Department of Otolaryngology - Head & Neck Surgery, Saga University Faculty of Medicine, Saga, Japan.
  • Okamura S; Department of Otolaryngology - Head & Neck Surgery, Saga University Faculty of Medicine, Saga, Japan.
  • Shuto H; Department of Otolaryngology - Head & Neck Surgery, Saga University Faculty of Medicine, Saga, Japan.
  • Tanaka N; Department of Otolaryngology - Head & Neck Surgery, Saga University Faculty of Medicine, Saga, Japan.
  • Hatayama E; Department of Otolaryngology - Head & Neck Surgery, Saga University Faculty of Medicine, Saga, Japan.
  • Shibamiya N; Department of Otolaryngology - Head & Neck Surgery, Saga University Faculty of Medicine, Saga, Japan.
  • Kuratomi Y; Department of Otolaryngology - Head & Neck Surgery, Saga University Faculty of Medicine, Saga, Japan.
In Vivo ; 37(3): 1275-1280, 2023.
Article en En | MEDLINE | ID: mdl-37103108
BACKGROUND/AIM: Chemoradiotherapy (CRT) with high-dose cisplatin has become the standard of care for larynx preservation in patients with locally advanced squamous cell carcinoma of the head and neck (LA-SCCHN). However, the long-term results are unsatisfactory. Induction chemotherapy (ICT) with docetaxel/cisplatin/5-fluorouracil (TPF) is associated with hematologic toxicity, and a safer therapy with comparable efficacy is desired. We conducted a pilot study to investigate the efficacy and safety of 5-fluorouracil/cisplatin/cetuximab (FPE) therapy as a candidate regimen for ICT in comparison with TPF. PATIENTS AND METHODS: Patients with stage cN2/3 LA-SCCHN of the larynx/oropharynx/hypopharynx were treated with FPE or TPF followed by radiotherapy. We reviewed patients' medical records and evaluated treatment efficacy and safety retrospectively. RESULTS: The response rates for ICT and ICT-radiotherapy were 71% and 93%, respectively, in the FPE group and 90% and 89%, respectively, in the TPF group. The 1-year progression-free and overall survival rates were 57% and 100%, respectively, in the FPE group and 70% and 90%, respectively, in the TPF group. TPF was linked to significantly higher rates of Grade 3/4 hematologic toxicity during ICT. The rates of Grade 3 or higher toxicity did not differ between the two groups during radiotherapy. CONCLUSION: The efficacy of ICT was comparable between the FPE and TPF groups, whereas FPE was associated with less toxicity. It is suggested that FPE therapy is an alternative ICT regimen to TPF therapy, but further long-term follow-up is needed.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Carcinoma de Células Escamosas / Neoplasias de Cabeza y Cuello Tipo de estudio: Observational_studies / Risk_factors_studies Límite: Humans Idioma: En Revista: In Vivo Asunto de la revista: NEOPLASIAS Año: 2023 Tipo del documento: Article País de afiliación: Japón Pais de publicación: Grecia
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Carcinoma de Células Escamosas / Neoplasias de Cabeza y Cuello Tipo de estudio: Observational_studies / Risk_factors_studies Límite: Humans Idioma: En Revista: In Vivo Asunto de la revista: NEOPLASIAS Año: 2023 Tipo del documento: Article País de afiliación: Japón Pais de publicación: Grecia